Comparison of high-resolution synchrotron-radiation-based phase-contrast imaging and absorption-contrast imaging for evaluating microstructure of vascular networks in rat brain: from 2D to 3D views

doi:10.1107/S1600577519011688

	Comparison of high-resolution synchrotron-radiation-based phase-contrast imaging and absorption-contrast imaging for evaluating microstructure of vascular networks in rat brain: from 2D to 3D views
	Li, Hong-Lei 3; Ding, Hui 3; Yin, Xian-Zhen 2; Chen, Zhuo-Hui 3; Tang, Bin 3; Sun, Jing-Yan 3; Hu, Xin-Hang 3; Lv, Xinyi 3; Kang, Shun-Tong 3; Fan, Yi-Shu 3
刊名	JOURNAL OF SYNCHROTRON RADIATION
	2019-11-01
卷号	26 页码:2024-2032
关键词	2D 3D brain microtomography synchrotron radiation vascular network
ISSN号	0909-0495
DOI	10.1107/S1600577519011688
通讯作者	Zhang, Meng-Qi(zhangmengqi8912@163.com)
英文摘要	Conventional imaging methods such as magnetic resonance imaging, computed tomography and digital subtraction angiography have limited temporospatial resolutions and shortcomings like invasive angiography, potential allergy to contrast agents, and image deformation, that restrict their application in high-resolution visualization of the structure of microvessels. In this study, through comparing synchrotron radiation (SR) absorption-contrast imaging to absorption phase-contrast imaging, it was found that SR-based phase-contrast imaging could provide more detailed ultra-high-pixel images of microvascular networks than absorption phase-contrast imaging. Simultaneously, SR-based phase-contrast imaging was used to perform high-quality, multi-dimensional and multi-scale imaging of rat brain angioarchitecture. With the aid of image post-processing, high-pixel-size two-dimensional virtual slices can be obtained without sectioning. The distribution of blood supply is in accordance with the results of traditional tissue staining. Three-dimensional anatomical maps of cerebral angioarchitecture can also be acquired. Functional partitions of regions of interest are reproduced in the reconstructed rat cerebral vascular networks. Imaging analysis of the same sample can also be displayed simultaneously in two- and three-dimensional views, which provides abundant anatomical information together with parenchyma and vessels. In conclusion, SR-based phase-contrast imaging holds great promise for visualizing microstructure of microvascular networks in two- and three-dimensional perspectives during the development of neurovascular diseases.
WOS关键词	COMPUTED-TOMOGRAPHY ; MAGNETIC-RESONANCE ; DISEASE ; MODEL ; MR ; ANGIOGENESIS ; ANGIOGRAPHY ; FLOW
WOS研究方向	Instruments & Instrumentation ; Optics ; Physics
语种	英语
出版者	INT UNION CRYSTALLOGRAPHY
WOS记录号	WOS:000496973400021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282469]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Meng-Qi
作者单位	1.Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Li, Hong-Lei,Ding, Hui,Yin, Xian-Zhen,et al. Comparison of high-resolution synchrotron-radiation-based phase-contrast imaging and absorption-contrast imaging for evaluating microstructure of vascular networks in rat brain: from 2D to 3D views[J]. JOURNAL OF SYNCHROTRON RADIATION,2019,26:2024-2032.
APA	Li, Hong-Lei.,Ding, Hui.,Yin, Xian-Zhen.,Chen, Zhuo-Hui.,Tang, Bin.,...&Zhang, Meng-Qi.(2019).Comparison of high-resolution synchrotron-radiation-based phase-contrast imaging and absorption-contrast imaging for evaluating microstructure of vascular networks in rat brain: from 2D to 3D views.JOURNAL OF SYNCHROTRON RADIATION,26,2024-2032.
MLA	Li, Hong-Lei,et al."Comparison of high-resolution synchrotron-radiation-based phase-contrast imaging and absorption-contrast imaging for evaluating microstructure of vascular networks in rat brain: from 2D to 3D views".JOURNAL OF SYNCHROTRON RADIATION 26(2019):2024-2032.