K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature

doi:10.1039/c9qo01174a

	K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature
	Mao, Xiaokang 3,4,5; Ni, Jiabin 2,3,5; Xu, Bin 1,4; Ding, Chunyong 2,3,5
刊名	ORGANIC CHEMISTRY FRONTIERS
	2020-01-21
卷号	7 期号:2 页码:350-354
ISSN号	2052-4129
DOI	10.1039/c9qo01174a
通讯作者	Xu, Bin() ; Ding, Chunyong(chding@simm.ac.cn)
英文摘要	A facile and efficient approach for the direct thiocyanation of pyrazolin-5-ones via a radical mechanism has been established for the first time. A series of 4-thiocyanated 5-hydroxy-1H-pyrazoles were synthesized in fair to good yields by K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with NH4SCN at room temperature under simple and mild reaction conditions with atom- and step-economy and good functional group tolerance.
资助项目	Personalized Medicines-Molecular Signature-based Drug Discovery and Development of Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020320] ; National Natural Science Foundation of China[81402790] ; National Natural Science Foundation of China[81430080] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002]
WOS关键词	ONE-POT SYNTHESIS ; C-H ACTIVATION ; ARYL THIOCYANATES ; SOLID ACID ; PYRAZOLONES ; ISOTHIOCYANATES ; EDARAVONE ; CATALYST ; ALKYNES ; ROUTE
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000508568000015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282393]
专题	中国科学院上海药物研究所
通讯作者	Xu, Bin; Ding, Chunyong
作者单位	1.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Shanghai Univ, Sch Mat Sci & Engn, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China 5.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Mao, Xiaokang,Ni, Jiabin,Xu, Bin,et al. K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature[J]. ORGANIC CHEMISTRY FRONTIERS,2020,7(2):350-354.
APA	Mao, Xiaokang,Ni, Jiabin,Xu, Bin,&Ding, Chunyong.(2020).K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature.ORGANIC CHEMISTRY FRONTIERS,7(2),350-354.
MLA	Mao, Xiaokang,et al."K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature".ORGANIC CHEMISTRY FRONTIERS 7.2(2020):350-354.