Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC | |
Li, Qian4; Zhang, Bing4; Cao, Hang4; Liu, Wei4; Guo, Fei1; Shen, Fuyi4; Ye, Binglu4; Liu, Huan3; Li, Yang1; Liu, Zhiqiang2,4 | |
刊名 | NEUROPHARMACOLOGY
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2020 | |
卷号 | 162页码:13 |
关键词 | Oxytocin mPFC Dopamine Antidepressant effect |
ISSN号 | 0028-3908 |
DOI | 10.1016/j.neuropharm.2019.107836 |
通讯作者 | Zhang, Bing(bingozzz@126.com) ; Li, Yang(liyang@simm.ac.cn) ; Liu, Zhiqiang(drliuzhiqiang@163.com) |
英文摘要 | Oxytocin (OT) and dopamine (DA) are two important elements that are closely related to mental and reward processes in the brain. OT controlled DA functional regulation contributes to various behaviours such as social reward, social cognition and emotion-related behaviours. Previous studies indicated that diminished dopaminergic transmission in the medial prefrontal cortex (mPFC) is correlated with the pathophysiology of depression. However, the interaction of OT and DA and their roles in antidepressant effects still require further exploration. Here, we investigated the antidepressant effect of OT through local mPFC administration, and further explored the underlying mechanisms that indicated that OT could strengthen dopaminergic synaptic transmission with OT receptor (OTR) activation dependent in the mPFC. Our results showed that local administration of OT in the mPFC exerts antidepressant (-like) effects in both naive and social defeat stress (SDS) depressive animal model. Mechanism study suggested that OT enhances DA level with OTR activation dependent, and elevated mPFC DA levels might further enhance excitatory synaptic transmission by activating the D1/PKA/DARPP32 intracellular signalling pathway in the mPFC. Hence, our study revealed that the activation of OTR strengthens excitatory synaptic transmission via the potentiation of dopaminergic synaptic transmission, especially via D1R activation dependent, in the mPFC, which may be the underlying mechanism of antidepressant (-like) effects mediated by OT. With specifically activation of the D1/PKA/DAPRR32 signalling pathway, our results may augment the important role of OT in reward circuits in the central nervous system. |
资助项目 | National Natural Science Foundation of China[81771188] ; National Natural Science Foundation of China[31671049] ; National Natural Science Foundation of China[81901376] ; Ministry of Science and Technology of the People's Republic of China[2013CB91060101] ; China Postdoctoral Science Foundation[2017M621535] ; Fundamental Research Funds for the Central Universities[22120180534] ; Shanghai Municipal Commission of Health and Family Planning[201740072] ; Science and Technology Commission of Shanghai Municipality[14411966700] ; Science and Technology Commission of Shanghai Municipality[16411967400] ; Pudong New Area Municipal Commission of Health and Family Planning[PW2016D-10] ; Personalized Medicines Molecular Signature -based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040302] ; Personalized Medicines Molecular Signature -based Drug Discovery and Development, Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040214] |
WOS关键词 | NUCLEUS-ACCUMBENS OXYTOCIN ; SOCIAL DEFEAT STRESS ; PREFRONTAL CORTEX ; RECEPTOR MODULATION ; MIDBRAIN DOPAMINE ; CEREBRAL-CORTEX ; BRAIN DOPAMINE ; BINDING-SITES ; DEPRESSION ; NEURONS |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000504504600020 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/282273] ![]() |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Zhang, Bing; Li, Yang; Liu, Zhiqiang |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Tongji Univ, Sch Med, Anesthesia & Brain Funct Res Inst, Shanghai 200082, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 4.Tongji Univ, Sch Med, Shanghai First Matern & Infant Hosp, Dept Anesthesiol, Shanghai 201204, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Qian,Zhang, Bing,Cao, Hang,et al. Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC[J]. NEUROPHARMACOLOGY,2020,162:13. |
APA | Li, Qian.,Zhang, Bing.,Cao, Hang.,Liu, Wei.,Guo, Fei.,...&Liu, Zhiqiang.(2020).Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC.NEUROPHARMACOLOGY,162,13. |
MLA | Li, Qian,et al."Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC".NEUROPHARMACOLOGY 162(2020):13. |
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