Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus

	Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus
	Tian, Yunong 2,3; Feng, Lu 4; Li, Bailin 2; Hu, Juanjuan 2; Xie, Jindan 2; Xiao, Wenjing 2; Nie, Linghui 1; Wu, Jiewei 2
刊名	CHEMICAL & PHARMACEUTICAL BULLETIN
	2019-11-01
卷号	67 期号:11 页码:1255-1258
关键词	ursane-type nortriterpene oleanane-type nortriterpene Rosa laevigata var. leiocapus anti-inflammatory
ISSN号	0009-2363
通讯作者	Nie, Linghui(nielinghui1213@163.com) ; Wu, Jiewei(wujiewei@gzucm.edu.cn)
英文摘要	One new 3,24-dinor-2,4-seco-ursane triterpene, rosanortriterpene C (1), together with four known compounds including 24-norursane-type nortriterpenes (2-3), 24-noroleanane-type nortriterpene (4), ursanetype triterpene (5), was isolated from the fruits of Rosa laevigata var. leiocapus. The new structure was elucidated through comprehensive spectroscopic analysis, including one dimensional (1D) and 2D NMR data, as well as electrospray ionization high resolution (HR-ESI) MS and IR spectrometry. Compounds 1-5 showed moderate anti-inflammatory activities against the production of nitric oxide (NO) in RAW264.7 cells stimulated by lipopolysaccharide (LPS) with IC50 values of 10.35 +/- 0.92, 14.28 +/- 1.20, 5.04 +/- 1.43, 29.29 +/- 3.64, and 14.37 +/- 0.59 mu M, respectively.
资助项目	State key Laboratory of Drug Research[SIMM1803KF-09]
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PHARMACEUTICAL SOC JAPAN
WOS记录号	WOS:000494055100013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281965]
专题	中国科学院上海药物研究所
通讯作者	Nie, Linghui; Wu, Jiewei
作者单位	1.Guangdong Second Prov Gen Hosp, Guangdong Tradit Med & Sports Injury Rehabil Res, Guangzhou 510317, Guangdong, Peoples R China 2.Guangzhou Univ Chinese Med, Math Engn Acad Chinese Med, Guangzhou 510006, Guangdong, Peoples R China 3.Guangzhou Univ, Sch Life Sci, Guangzhou 510006, Guangdong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Materia Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Tian, Yunong,Feng, Lu,Li, Bailin,et al. Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2019,67(11):1255-1258.
APA	Tian, Yunong.,Feng, Lu.,Li, Bailin.,Hu, Juanjuan.,Xie, Jindan.,...&Wu, Jiewei.(2019).Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus.CHEMICAL & PHARMACEUTICAL BULLETIN,67(11),1255-1258.
MLA	Tian, Yunong,et al."Rosanortriterpene C, a 3,24-Dinor-2,4-seco-ursane Triterpene from the Fruits of Rosa laevigata var. leiocapus".CHEMICAL & PHARMACEUTICAL BULLETIN 67.11(2019):1255-1258.