Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities

doi:10.1021/acs.orglett.9b02909

	Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities
	Zhang, Rui 1,5,6; Tang, Chunping 1,6; Liu, Hong-Chun 2; Ren, Yongmei 1,4,5,6; Ke, Chang-Qiang 1,6; Yao, Sheng 1,6; Cai, Yaoyao 3; Zhang, Naixia 3; Ye, Yang 1,4,6
刊名	ORGANIC LETTERS
	2019-10-18
卷号	21 期号:20 页码:8211-8214
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b02909
通讯作者	Ye, Yang(yye@simm.ac.cn)
英文摘要	Two guaianolide sesquiterpenoid tetramers named ainsliatetramers A and B were separated from Ainsliaea fragrans. Through spectroscopic analyses, especially the band-selective CT-HSQC and CT-HMBC techniques, the complex skeleton was constructed from four sesquiterpene units via three different linkages. A biosynthetic pathway was proposed featuring a Michael addition and a regular and a hetero-Diels-Alder cycloaddition. Both exhibited potent cytotoxicity against human cancer cell lines with IC50 values ranging from 2 to 15 mu M.
资助项目	National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2015ZX09103002] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; International Partnership Program of Chinese Academy of Sciences[153631KYSB20160004] ; International Partnership Program of Chinese Academy of Sciences[153631KYSB20170043]
WOS关键词	ALKALOIDS ; SKELETON ; TRIMERS ; DIMER
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000492114600015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281909]
专题	中国科学院上海药物研究所
通讯作者	Ye, Yang
作者单位	1.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Div Antitumor Pharmacol, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Dept Analyt Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Rui,Tang, Chunping,Liu, Hong-Chun,et al. Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities[J]. ORGANIC LETTERS,2019,21(20):8211-8214.
APA	Zhang, Rui.,Tang, Chunping.,Liu, Hong-Chun.,Ren, Yongmei.,Ke, Chang-Qiang.,...&Ye, Yang.(2019).Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities.ORGANIC LETTERS,21(20),8211-8214.
MLA	Zhang, Rui,et al."Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities".ORGANIC LETTERS 21.20(2019):8211-8214.