Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma

doi:10.1186/s12935-019-1074-9

	Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma
	Ma, Rong 2,3; Zhao, Yanyun 2,3; He, Miao 2,3; Zhao, Hongliang 2,3; Zhang, Yifan 2,3; Zhou, Shuqi 2,3; Gao, Mengcong 2,3; Di, Di 2,3; Wang, Jue 2,3; Ding, Jian 1,2
刊名	CANCER CELL INTERNATIONAL
	2019-12-30
卷号	19 期号:1 页码:16
关键词	Colon adenocarcinoma MicroRNAs Biomarker Prognosis
DOI	10.1186/s12935-019-1074-9
通讯作者	Ding, Jian(jding@simm.ac.cn) ; Wei, Minjie(weiminjiecmu@163.com)
英文摘要	Background Increasing studies have suggested that aberrant expression of microRNAs might play essential roles in the progression of cancers. In this study, we sought to construct a high-specific and superior microRNAs signature to improve the survival prediction of colon adenocarcinoma (COAD) patients. Methods The genome-wide miRNAs, mRNA and lncRNA expression profiles and corresponding clinical information of COAD were collected from the TCGA database. Differential expression analysis, Kaplan-Meier curve and time-dependent ROC curve were calculated and performed using R software and GraphPad Prism7. Univariate and multivariate Cox analysis was performed to evaluate the prognostic ability of signature. Functional enrichment analysis was analyzed using STRING database. Results We identified ten prognosis-related microRNAs, including seven risky factors (hsa-miR-197, hsa-miR-32, hsa-miR-887, hsa-miR-3199-2, hsa-miR-4999, hsa-miR-561, hsa-miR-210) and three protective factors (hsa-miR-3917, hsa-miR-3189, hsa-miR-6854). The Kaplan-Meier survival analysis showed that the patients with high risk score had shorter overall survival (OS) in test series. And the similar results were observed in both validation and entire series. The time-dependent ROC curve suggested this signature have high accuracy of OS for COAD. The Multivariate Cox regression analysis and stratification analysis suggested that the ten-microRNA signature was an independent factor after being adjusted with other clinical characteristics. In addition, we also found microRNA signature have higher AUC than other signature. Furthermore, we identified some miRNA-target genes that affect lymphatic metastasis and invasion of COAD patients. Conclusion In this study, we established a ten-microRNA signature as a potentially reliable and independent biomarker for survival prediction of COAD patients.
资助项目	National Natural Science Foundation of China and Liaoning joint fund key program[U1608281] ; Double Hundred Program for Shenyang Scientific and Technological Innovation Projects[Z18-4-020] ; Double Hundred Program for Shenyang Scientific and Technological Innovation Projects[100040]
WOS关键词	NONCODING RNA SIGNATURE ; COLORECTAL-CANCER ; METASTASIS ; MICRORNAS ; HETEROGENEITY ; CARCINOMA ; SURVIVAL ; INVASION
WOS研究方向	Oncology
语种	英语
出版者	BMC
WOS记录号	WOS:000513526700003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281751]
专题	中国科学院上海药物研究所
通讯作者	Ding, Jian; Wei, Minjie
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai, Peoples R China 2.China Med Univ, Sch Pharm, Dept Pharmacol, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China 3.China Med Univ, Liaoning Engn Technol Res Ctr, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Ma, Rong,Zhao, Yanyun,He, Miao,et al. Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma[J]. CANCER CELL INTERNATIONAL,2019,19(1):16.
APA	Ma, Rong.,Zhao, Yanyun.,He, Miao.,Zhao, Hongliang.,Zhang, Yifan.,...&Wei, Minjie.(2019).Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma.CANCER CELL INTERNATIONAL,19(1),16.
MLA	Ma, Rong,et al."Identifying a ten-microRNA signature as a superior prognosis biomarker in colon adenocarcinoma".CANCER CELL INTERNATIONAL 19.1(2019):16.