Crokonoids A-C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis

doi:10.1021/acs.orglett.9b04484

	Crokonoids A-C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis
	Fan, Yao-Yue 2; Shi, Shu-Qin 1; Deng, Guo-Zhen 2,3; Liu, Hong-Chun 2; Xu, Cheng-Hui 2; Ding, Jian 2; Wang, Guan-Wu 1; Yue, Jian-Min 2
刊名	ORGANIC LETTERS
	2020-02-07
卷号	22 期号:3 页码:929-933
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b04484
通讯作者	Wang, Guan-Wu(gwang@ustc.edu.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要	Crokonoid A (1), a highly rearranged diterpenoid featuring a dual-bridged tricyclo[4.4.1.1(1,4)]dodecane-2,11-dione ring system and its two possible ent-kaurene diterpenoid precursors (2 and 3), was isolated and structurally characterized by solid data from Croton kongensis. Compound 1 exhibited significant cytotoxicity against HL-60 and A-549 cell lines with IC50 values of 1.24 +/- 0.56 and 1.92 +/- 0.60 mu M, respectively.
资助项目	National Natural Science Foundation of China[21532007] ; National Natural Science Foundation of China[21772213] ; Drug Innovation Major Project of China[2018ZX09711001-001-005] ; Biological Resources Program, CAS of China[KFJBRP-008] ; Shanghai Rising-Star Program Foundation (SCST)[19QA1410800] ; Youth Innovation Promotion Association CAS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000513082700034
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281479]
专题	中国科学院上海药物研究所
通讯作者	Wang, Guan-Wu; Yue, Jian-Min
作者单位	1.Univ Sci & Technol China, Suzhou, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Fan, Yao-Yue,Shi, Shu-Qin,Deng, Guo-Zhen,et al. Crokonoids A-C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis[J]. ORGANIC LETTERS,2020,22(3):929-933.
APA	Fan, Yao-Yue.,Shi, Shu-Qin.,Deng, Guo-Zhen.,Liu, Hong-Chun.,Xu, Cheng-Hui.,...&Yue, Jian-Min.(2020).Crokonoids A-C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis.ORGANIC LETTERS,22(3),929-933.
MLA	Fan, Yao-Yue,et al."Crokonoids A-C, A Highly Rearranged and Dual-Bridged Spiro Diterpenoid and Two Other Diterpenoids from Croton kongensis".ORGANIC LETTERS 22.3(2020):929-933.