Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets

doi:10.1016/j.ajps.2019.01.001

	Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets
	Zhang, Liu 1,2; Shakya, Shailendra 2; Wu, Li 2; Wang, Jiangtao 3; Jin, Guanghui 3; Sun, Huimin 4; Yin, Xianzhen 2; Sun, Lixin 1; Zhang, Jiwen 1,2
刊名	ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2020
卷号	15 期号:1 页码:60-68
关键词	Stearic acid Morphology Spatial distribution SR-mu CT Glipizide tablets
ISSN号	1818-0876
DOI	10.1016/j.ajps.2019.01.001
通讯作者	Yin, Xianzhen(yinxianzhen0001@163.com) ; Sun, Lixin(slx04@163.com) ; Zhang, Jiwen(jwzhang@simm.ac.cn)
英文摘要	The shapes of particles and their distribution in tablets, controlled by pretreatment and tableting process, determine the pharmaceutical performance of excipient like lubricant. This study aims to provide deeper insights to the relationship of the morphology and spatial distribution of stearic acid (SA) with the lubrication efficiency, as well as the resulting tablet property. Unmodified SA particles as flat sheet-like particles were firstly reprocessed by emulsification in hot water to obtain the reprocessed SA particles with spherical morphology. The three-dimensional (3D) information of SA particles in tablets was detected by a quantitative and non-invasive 3D structure elucidation technique, namely, synchrotron radiation X-ray micro-computed tomography (SR-mu CT). SA particles in glipizide tablets prepared by using unmodified SA (GUT), reprocessed SA (GRT), as well as reference listed drug (RLD) of glipizide tablets were analyzed by SR-mu CT. The results showed that the reprocessed SA with better flowability contributed to similarity of breaking forces between that of GRT and RLD. SA particles in GRT were very similar to those in RLD with uniform morphology and particle size, while SA particles in GUT were not evenly distributed. These findings not only demonstrated the feasibility of SR-pCT as a new method in revealing the morphology and spatial distribution of excipient in drug delivery system, but also deepened insights of solid dosage form design into a new scale by powder engineering. (C) 2019 Shenyang Pharmaceutical University. Published by Elsevier B.V.
资助项目	National Science and Technology Major Project[2017ZX09101001-006]
WOS关键词	PHARMACEUTICAL TABLETS ; CONTROLLED-RELEASE ; DRUG-RELEASE ; RAY ; QUANTIFICATION ; COMPONENTS ; EXCIPIENT
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	SHENYANG PHARMACEUTICAL UNIV
WOS记录号	WOS:000519619600005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281180]
专题	中国科学院上海药物研究所
通讯作者	Yin, Xianzhen; Sun, Lixin; Zhang, Jiwen
作者单位	1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Weihai Disu Pharmaceut Manufacturer, Weihai 264200, Peoples R China 4.Natl Inst Food & Drug Control, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Liu,Shakya, Shailendra,Wu, Li,et al. Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets[J]. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2020,15(1):60-68.
APA	Zhang, Liu.,Shakya, Shailendra.,Wu, Li.,Wang, Jiangtao.,Jin, Guanghui.,...&Zhang, Jiwen.(2020).Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets.ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES,15(1),60-68.
MLA	Zhang, Liu,et al."Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their distribution in tablets".ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 15.1(2020):60-68.