Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats

doi:10.1007/s12264-019-00450-0

	Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats
	Gu, Pan 1; Xu, Zi-Hao 1; Cao, Yu-Ze 1; Liao, Sheng-Hui 2; Deng, Qian-Fang 1; Yin, Xian-Zhen 3; Wang, Zhuo-Lu 4; Chen, Zhuo-Hui 1; Hu, Xin-Hang 1; Wang, Hui 1
刊名	NEUROSCIENCE BULLETIN
	2020-04-01
卷号	36 期号:4 页码:333-345
关键词	Epilepsy Synchrotron radiation 3D Angioarchitecture Blood vessel Remodeling
ISSN号	1673-7067
DOI	10.1007/s12264-019-00450-0
通讯作者	Xiao, Bo(csuxiaobo123456@163.com) ; Zhang, Meng-Qi(zhangmengqi8912@163.com)
英文摘要	Characterizing the three-dimensional (3D) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy. However, conventional imaging techniques cannot detect microvessels on micron/sub-micron scales without angiography. In this study, synchrotron radiation (SR)-based X-ray in-line phase-contrast imaging (ILPCI) and quantitative 3D characterization were used to acquire high-resolution, high-contrast images of rat brain tissue under both normal and seizure conditions. The number of blood microvessels was markedly increased on days 1 and 14, but decreased on day 60 after seizures. The surface area, diameter distribution, mean tortuosity, and number of bifurcations and network segments also showed similar trends. These pathological changes were confirmed by histological tests. Thus, SR-based ILPCI provides systematic and detailed views of cerebrovascular anatomy at the micron level without using contrast-enhancing agents. This holds considerable promise for better diagnosis and understanding of the pathogenesis and development of epilepsy.
WOS关键词	GROWTH-FACTOR ; BRAIN ; SEIZURE ; ANGIOGENESIS ; NETWORK ; CANCER ; CELLS ; PROGRESSION ; ASSOCIATION ; TOMOGRAPHY
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000524876000002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281036]
专题	中国科学院上海药物研究所
通讯作者	Xiao, Bo; Zhang, Meng-Qi
作者单位	1.Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China 2.Cent South Univ, Sch Informat Sci & Engn, Changsha 410008, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Hunan Prov Maternal & Child Hlth Care Hosp, Dept Breast Surg, Changsha 410008, Peoples R China 5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China
推荐引用方式 GB/T 7714	Gu, Pan,Xu, Zi-Hao,Cao, Yu-Ze,et al. Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats[J]. NEUROSCIENCE BULLETIN,2020,36(4):333-345.
APA	Gu, Pan.,Xu, Zi-Hao.,Cao, Yu-Ze.,Liao, Sheng-Hui.,Deng, Qian-Fang.,...&Zhang, Meng-Qi.(2020).Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats.NEUROSCIENCE BULLETIN,36(4),333-345.
MLA	Gu, Pan,et al."Synchrotron Radiation-Based Three-Dimensional Visualization of Angioarchitectural Remodeling in Hippocampus of Epileptic Rats".NEUROSCIENCE BULLETIN 36.4(2020):333-345.