Pd(II)-Catalyzed Asymmetric Annulation toward the Synthesis of 2,3-Disubstituted Chiral Indenols

doi:10.1021/acs.joc.9b02958

	Pd(II)-Catalyzed Asymmetric Annulation toward the Synthesis of 2,3-Disubstituted Chiral Indenols
	Gu, Chang-Xue 1; Chen, Wen-Wen 1; Xu, Ming-Hua 1,2,3
刊名	JOURNAL OF ORGANIC CHEMISTRY
	2020-03-06
卷号	85 期号:5 页码:3887-3893
ISSN号	0022-3263
DOI	10.1021/acs.joc.9b02958
通讯作者	Chen, Wen-Wen(wenwen@shnu.edu.cn) ; Xu, Ming-Hua(xumh@sustech.edu.cn)
英文摘要	An enantioselective asymmetric annulation of 2-formylboronic acids with internal alkynes has been realized using a chiral phosphinooxazoline/palladium(II) catalyst. The reaction tolerates a variety of alkynes including the relatively inert diaryl substituted internal ones. A wide range of optically active 2,3-disubstituted indenols was afforded in high yields with good to excellent enantioselectivities (up to 99% yield and 99% ee).
资助项目	National Science AMP; Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[21672229] ; Shanghai Municipal Committee of Science and Technology[18ZR1447600] ; SA-SIBS Scholarship Program
WOS关键词	CATALYZED REGIOSELECTIVE CARBOCYCLIZATION ; O-IODOPHENYL KETONES ; ACIDS ; ALKYNES ; ROUTE
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000518875700093
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280836]
专题	中国科学院上海药物研究所
通讯作者	Chen, Wen-Wen; Xu, Ming-Hua
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China
推荐引用方式 GB/T 7714	Gu, Chang-Xue,Chen, Wen-Wen,Xu, Ming-Hua. Pd(II)-Catalyzed Asymmetric Annulation toward the Synthesis of 2,3-Disubstituted Chiral Indenols[J]. JOURNAL OF ORGANIC CHEMISTRY,2020,85(5):3887-3893.
APA	Gu, Chang-Xue,Chen, Wen-Wen,&Xu, Ming-Hua.(2020).Pd(II)-Catalyzed Asymmetric Annulation toward the Synthesis of 2,3-Disubstituted Chiral Indenols.JOURNAL OF ORGANIC CHEMISTRY,85(5),3887-3893.
MLA	Gu, Chang-Xue,et al."Pd(II)-Catalyzed Asymmetric Annulation toward the Synthesis of 2,3-Disubstituted Chiral Indenols".JOURNAL OF ORGANIC CHEMISTRY 85.5(2020):3887-3893.