Design of heterostructured hybrids comprising ultrathin 2D bismuth tungstate nanosheets reinforced by chloramphenicol imprinted polymers used as biomimetic interfaces for mass-sensitive detection

doi:10.1016/j.colsurfb.2020.110775

	Design of heterostructured hybrids comprising ultrathin 2D bismuth tungstate nanosheets reinforced by chloramphenicol imprinted polymers used as biomimetic interfaces for mass-sensitive detection
	Shaheen, Ayesha 2,3; Taj, Ayesha 2,3; Lieberzeit, Peter A.1; Mujahid, Adnan 4; Hameed, Sadaf 5; Yu, Haijun 6,7; Mahmood, Arshad 8; Webster, Thomas J.9; Rashid, M. Hamid 2; Khan, Waheed S.2
刊名	COLLOIDS AND SURFACES B-BIOINTERFACES
	2020-04-01
卷号	188 页码:10
关键词	Nanomaterials Nanohybrids Bismuth tungstate Molecularly imprinted polymers Mass-sensitive
ISSN号	0927-7765
DOI	10.1016/j.colsurfb.2020.110775
通讯作者	Khan, Waheed S.(waheedskhan@nibge.org) ; Bajwa, Sadia Z.(sadia.zafar.bajwa@nibge.org)
英文摘要	Combining nanomaterials in varying morphology and functionalities gives rise to a new class of composite materials leading to innovative applications. In this study, we designed a heterostructured hybrid material consisting of two-dimensional bismuth nanosheets augmented by molecularly imprinted networks. Antibiotic overuse is now one of the main concerns in health management, and their monitoring is highly desirable but challenging. So, for this purpose, the resulting composite interface was used as a transducer for quartz crystal microbalances. The main objective was to develop highly selective mass-sensitive sensor for chloramphenicol. Morphological investigation revealed the presence of ultrathin, square shaped nanosheets, 2-3 nm in height and further supplemented by imprinted polymers. Sensor responses are described as the decrease in the frequency of microbalances owing to chloramphenicol re-binding in the templated cavities, yielding a detection limit down to 0.74 mu M. This sensor demonstrated a 100 % specific detection of chloramphenicol over its interfering and structural analogs (clindamycin, thiamphenicol, and florfenicol). This composite interface offers the advantage of selective binding and excellent sensitivity due to special heterostructured morphology, in addition to benefits of robustness and online monitoring. The results suggest that such composite-based sensors can be favorable platforms, especially for commercial prospects, to obtain selective detection of other biomolecules of clinical importance.
资助项目	International Foundation for Science (IFS)[E-5659] ; Organization of Islamic Cooperation's (OIC) Standing Committee on Scientific and Technological Cooperation (COMSTECH)[E-5659] ; Higher Education Commission of Pakistan (HEC)[6116] ; Higher Education Commission of Pakistan (HEC)[6117]
WOS关键词	METAL-ORGANIC FRAMEWORK ; SOLID-PHASE EXTRACTION ; ELECTROCHEMICAL DETERMINATION ; PHOTOCATALYTIC ACTIVITY ; RESIDUAL AMOUNTS ; GRAPHENE OXIDE ; LC-MS/MS ; VALIDATION ; HPLC ; THIAMPHENICOL
WOS研究方向	Biophysics ; Chemistry ; Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000527305100019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280622]
专题	中国科学院上海药物研究所
通讯作者	Khan, Waheed S.; Bajwa, Sadia Z.
作者单位	1.Univ Vienna, Fac Chem, Dept Phys Chem, A-1090 Vienna, Austria 2.NIBGE, Nanobiotech Grp, POB 577,Jhang Rd, Faisalabad, Pakistan 3.Pakistan Inst Engn & Appl Sci, Islamabad, Pakistan 4.Univ Punjab, Inst Chem, Quaid I Azam Campus, Lahore 54590, Pakistan 5.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China 6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 7.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 8.Natl Inst Lasers & Optron, Islamabad 45650, Pakistan 9.Northeastern Univ, Dept Chem Engn, Boston, MA 02115 USA
推荐引用方式 GB/T 7714	Shaheen, Ayesha,Taj, Ayesha,Lieberzeit, Peter A.,et al. Design of heterostructured hybrids comprising ultrathin 2D bismuth tungstate nanosheets reinforced by chloramphenicol imprinted polymers used as biomimetic interfaces for mass-sensitive detection[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2020,188:10.
APA	Shaheen, Ayesha.,Taj, Ayesha.,Lieberzeit, Peter A..,Mujahid, Adnan.,Hameed, Sadaf.,...&Bajwa, Sadia Z..(2020).Design of heterostructured hybrids comprising ultrathin 2D bismuth tungstate nanosheets reinforced by chloramphenicol imprinted polymers used as biomimetic interfaces for mass-sensitive detection.COLLOIDS AND SURFACES B-BIOINTERFACES,188,10.
MLA	Shaheen, Ayesha,et al."Design of heterostructured hybrids comprising ultrathin 2D bismuth tungstate nanosheets reinforced by chloramphenicol imprinted polymers used as biomimetic interfaces for mass-sensitive detection".COLLOIDS AND SURFACES B-BIOINTERFACES 188(2020):10.