Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA

doi:10.1021/acs.orglett.0c01016

	Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA
	Wu, Wenting 1; Sun, Zhen 1; Wang, Xuan 1,2; Lu, Xiaojie 2; Dai, Dongcheng 1
刊名	ORGANIC LETTERS
	2020-04-17
卷号	22 期号:8 页码:3239-3244
ISSN号	1523-7060
DOI	10.1021/acs.orglett.0c01016
通讯作者	Dai, Dongcheng(ddai@amgen.com)
英文摘要	An efficient and facile formal [4 + 2] cycloaddition reaction was developed to synthesize diverse thiazole-fused dihydropyrans (TFDP) on DNA. Mild reaction conditions, broad substrate scope, and compatibility with subsequent enzymatic ligation demonstrated the utility of this methodology in DNA-encoded library synthesis.
WOS关键词	ENCODED CHEMICAL LIBRARIES ; ANNULATION ; ALDEHYDES ; POTENT
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000526894000075
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280493]
专题	中国科学院上海药物研究所
通讯作者	Dai, Dongcheng
作者单位	1.Amgen Res, Amgen Asia R&D Ctr, Dept Therapeut Discovery, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wu, Wenting,Sun, Zhen,Wang, Xuan,et al. Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA[J]. ORGANIC LETTERS,2020,22(8):3239-3244.
APA	Wu, Wenting,Sun, Zhen,Wang, Xuan,Lu, Xiaojie,&Dai, Dongcheng.(2020).Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA.ORGANIC LETTERS,22(8),3239-3244.
MLA	Wu, Wenting,et al."Construction of Thiazole-Fused Dihydropyrans via Formal [4+2] Cycloaddition Reaction on DNA".ORGANIC LETTERS 22.8(2020):3239-3244.