synchrotronradiationbasedthreedimensionalvisualizationofangioarchitecturalremodelinginhippocampusofepilepticrats

doi:10.1007/s12264-019-00450-0

	synchrotronradiationbasedthreedimensionalvisualizationofangioarchitecturalremodelinginhippocampusofepilepticrats
	Gu Pan 2; Xu Zihao 2; Cao Yuze 2; Liao Shenghui 3; Deng Qianfang 2; Yin Xianzhen 4; Wang Zhuolu 1; Chen Zhuohui 2; Hu Xinhang 2; Wang Hui 2
刊名	neurosciencebulletin
	2020
卷号	36 期号:4 页码:333
关键词	Epilepsy Synchrotron radiation 3D Angioarchitecture Blood vessel Remodeling
ISSN号	1673-7067
DOI	10.1007/s12264-019-00450-0
英文摘要	Characterizing the three-dimensional(3D) morphological alterations of microvessels under both normal and seizure conditions is crucial for a better understanding of epilepsy. However, conventional imaging techniques cannot detect microvessels on micron/sub-micron scales without angiography. In this study, synchrotron radiation(SR)-based X-ray in-line phase-contrast imaging(ILPCI) and quantitative 3D characterization were used to acquire high-resolution, high-contrast images of rat brain tissue under both normal and seizure conditions. The number of blood microvessels was markedly increased on days 1 and 14, but decreased on day 60 after seizures. The surface area, diameter distribution, mean tortuosity, and number of bifurcations and network segments also showed similar trends. These pathological changes were confirmed by histological tests. Thus, SR-based ILPCI provides systematic and detailed views of cerebrovascular anatomy at the micron level without using contrast-enhancing agents. This holds considerable promise for better diagnosis and understanding of the pathogenesis and development of epilepsy.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280158]
专题	中国科学院上海药物研究所
作者单位	1.Department of Breast Surgery,Hunan Provincial Maternal and Child Health Care Hospital 2.Department of Neurology,Xiangya Hospital,Central South University 3.School of Information Science and Engineering,Central South University 4.中国科学院上海药物研究所 5.Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Gu Pan,Xu Zihao,Cao Yuze,et al. synchrotronradiationbasedthreedimensionalvisualizationofangioarchitecturalremodelinginhippocampusofepilepticrats[J]. neurosciencebulletin,2020,36(4):333.
APA	Gu Pan.,Xu Zihao.,Cao Yuze.,Liao Shenghui.,Deng Qianfang.,...&Zhang Mengqi.(2020).synchrotronradiationbasedthreedimensionalvisualizationofangioarchitecturalremodelinginhippocampusofepilepticrats.neurosciencebulletin,36(4),333.
MLA	Gu Pan,et al."synchrotronradiationbasedthreedimensionalvisualizationofangioarchitecturalremodelinginhippocampusofepilepticrats".neurosciencebulletin 36.4(2020):333.