3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis

doi:10.1016/j.cell.2021.01.001

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	3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis
	Luo, Xin 1,2,4,5; Liu, Yuting 6; Dang, Dachang 7; Hu, Ting 1,3,5; Hou, Yingping 8; Meng, Xiaoyu 1,3,5; Zhang, Fengyun 1,3,5; Li, Tingting 6; Wang, Can 7; Li, Min 5
刊名	CELL
	2021-02-04
卷号	184 期号:3 页码:723-+
ISSN号	0092-8674
DOI	10.1016/j.cell.2021.01.001
英文摘要	Elucidating the regulatory mechanisms of human brain evolution is essential to understanding human cognition and mental disorders. We generated multi-omics profiles and constructed a high-resolution map of 3D genome architecture of rhesus macaque during corticogenesis. By comparing the 3D genomes of human, macaque, and mouse brains, we identified many human-specific chromatin structure changes, including 499 topologically associating domains (TADs) and 1,266 chromatin loops. The human-specific loops are significantly enriched in enhancer-enhancer interactions, and the regulated genes show human-specific expression changes in the subplate, a transient zone of the developing brain critical for neural circuit formation and plasticity. Notably, many human-specific sequence changes are located in the human-specific TAD boundaries and loop anchors, which may generate new transcription factor binding sites and chromatin structures in human. Collectively, the presented data highlight the value of comparative 3D genome analyses in dissecting the regulatory mechanisms of brain development and evolution.
资助项目	Strategic Priority Research Program[XDB13010000] ; National Natural Science Foundation of China[U2002207] ; National Natural Science Foundation of China[31730088] ; National Natural Science Foundation of China[31621062] ; National Natural Science Foundation of China[91631306] ; National Natural Science Foundation of China[32000406] ; National Natural Science Foundation of China[31871266] ; National Natural Science Foundation of China[71532001] ; National Natural Science Foundation of China[11661141019] ; National Natural Science Foundation of China[2019YFA0709501] ; National Natural Science Foundation of China[61621003] ; National Key Research and Development Program of China[2016YFA0100103] ; National Ten Thousand Talent Program for Young Top-notch Talents ; Ten Thousand Talents Project of Yunnan Province of China
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000629631400014
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/58402]
专题	应用数学研究所
通讯作者	Zhang, Shihua; Li, Cheng; Su, Bing
作者单位	1.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, Kunming Primate Res Ctr, Natl Resource Ctr Nonhuman Primates, Kunming 650107, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Kunming Coll Life Sci, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Kunming Inst Zool, Natl Res Facil Phenotyp & Genet Anal Model Anim P, Kunming 650107, Yunnan, Peoples R China 5.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China 6.Peking Univ, Ctr Bioinformat, Ctr Stat Sci, Sch Life Sci, Beijing 100871, Peoples R China 7.Chinese Acad Sci, Acad Math & Syst Sci, RCSDS, NCMIS,CEMS, Beijing 100190, Peoples R China 8.Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Luo, Xin,Liu, Yuting,Dang, Dachang,et al. 3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis[J]. CELL,2021,184(3):723-+.
APA	Luo, Xin.,Liu, Yuting.,Dang, Dachang.,Hu, Ting.,Hou, Yingping.,...&Su, Bing.(2021).3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis.CELL,184(3),723-+.
MLA	Luo, Xin,et al."3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis".CELL 184.3(2021):723-+.