A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study

doi:10.1002/sim.8912

	A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study
	Li, Zhengbang 1; Qin, Sanan 1; Li, Qizhai 2,3
刊名	STATISTICS IN MEDICINE
	2021-05-10
卷号	40 期号:10 页码:2422-2434
关键词	asymptotic distribution maximum minimum power Z‐ score
ISSN号	0277-6715
DOI	10.1002/sim.8912
英文摘要	In this article, we propose a novel test via combining the maximum and minimum values among a large number of dependent Z-scores for testing the hypothesis with sparse signals. The proposed test employs the information about different signs of maximum and minimum Z-scores and thus power is gained. Its asymptotic null distribution is derived under the null hypothesis and some regular conditions. Extensive simulation studies are conducted to show the advantages of the proposed test by comparing with two existing ones. A real application to the lipids genome wide association study further shows its performances.
资助项目	Beijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; Self-determined research funds of CCNU from the colleges' basic research of MOE[CCNU20TS002]
WOS研究方向	Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics
语种	英语
出版者	WILEY
WOS记录号	WOS:000625327800001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/58314]
专题	中国科学院数学与系统科学研究院
通讯作者	Li, Qizhai
作者单位	1.Cent China Normal Univ, Sch Math & Stat, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, LSC, Zhongguancun East Rd,55, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Zhengbang,Qin, Sanan,Li, Qizhai. A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study[J]. STATISTICS IN MEDICINE,2021,40(10):2422-2434.
APA	Li, Zhengbang,Qin, Sanan,&Li, Qizhai.(2021).A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study.STATISTICS IN MEDICINE,40(10),2422-2434.
MLA	Li, Zhengbang,et al."A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study".STATISTICS IN MEDICINE 40.10(2021):2422-2434.