AssocTests: An R Package for Genetic Association Studies

doi:10.18637/iss.v04.i05

	AssocTests: An R Package for Genetic Association Studies
	Wang, Lin 2; Zhang, Wei 3; Li, Qizhai 1,3
刊名	JOURNAL OF STATISTICAL SOFTWARE
	2020-06-01
卷号	94 期号:5 页码:1-26
关键词	distance regression genetic association studies population stratification Tracy-Widom test R
ISSN号	1548-7660
DOI	10.18637/iss.v04.i05
英文摘要	The R package AssocTests provides some procedures which are commonly used in genetic association studies. These procedures are population stratification correction through eigenvectors, principal coordinates of clusterings, Tracy-Widom test, distance regression, single-marker test, maximum test based on three Cochran-Armitage trend tests, non-parametric trend test, and non-parametric maximum test. The trait values for these methods should be discrete or continuous. The discrete traits can be coded by 1/0 for cases/controls. The genotype values can be 0, 1, or 2 indicating the number of risk alleles for a biallelic single-nucleotide polymorphism. This article introduces the methods and algorithms implemented in the package. Some examples are provided to illustrate the package's capability.
资助项目	Special National Key Research and Development Plan[2016YFD0400206] ; Beijing Natural Science Foundation[Z180006] ; National Science Foundation of China[11722113] ; National Nature Science Foundation of China[11701391] ; Scientific Research Level Improvement Quota Project of Capital University of Economics and Business ; 100 Talents Program of The Chinese Academy of Sciences for Young Scholars ; National Institutes of Health[NO1-AR-2-2263] ; National Institutes of Health[RO1-AR-44422] ; National Arthritis Foundation
WOS研究方向	Computer Science ; Mathematics
语种	英语
出版者	JOURNAL STATISTICAL SOFTWARE
WOS记录号	WOS:000552355700001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/51858]
专题	中国科学院数学与系统科学研究院
通讯作者	Li, Qizhai
作者单位	1.Univ Chinese Acad Sci, Sch Math Sci, Beijing 100049, Peoples R China 2.Capital Univ Econ & Business, Sch Stat, 121 Zhangjialukou, Beijing 100070, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, LSC, 55 Zhongguancun East Rd, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lin,Zhang, Wei,Li, Qizhai. AssocTests: An R Package for Genetic Association Studies[J]. JOURNAL OF STATISTICAL SOFTWARE,2020,94(5):1-26.
APA	Wang, Lin,Zhang, Wei,&Li, Qizhai.(2020).AssocTests: An R Package for Genetic Association Studies.JOURNAL OF STATISTICAL SOFTWARE,94(5),1-26.
MLA	Wang, Lin,et al."AssocTests: An R Package for Genetic Association Studies".JOURNAL OF STATISTICAL SOFTWARE 94.5(2020):1-26.