The elastic theory of a single DNA molecule

	The elastic theory of a single DNA molecule
	Ou-Yang, ZC; Zhou, H; Mang, Y
	2003
会议日期	JUN 16-19, 2002
会议地点	UNIV TSINGHUA, BEIJING, PEOPLES R CHINA
关键词	DOUBLE-STRANDED DNA POLYNUCLEOTIDE CHAINS STACKING INTERACTIONS TRANSITIONS POLYMERASE
页码	445-455
英文摘要	We review our recent efforts in understanding the elastic properties of double-stranded (ds) and single-stranded (ss) DNA macromolecules. A simple geometric model of dsDNA were constructed and solved by path integral methods. The good agreement with experiments on dsDNA's entropic elasticity, cooperative extensibility, and supercoiling property suggested that the short-ranged base-pair stacking interaction is crucial for the stability and the highly deformability of dsDNA. For ssDNA at high ionic conditions, base-pairing and base-pair stacking interactions cause the polymer to fold into compact hairpin configurations. The force-induced hairpin-coil transition were studied with generating function method. In accordance with experiment, this transition was found to be highly cooperative when the average stacking potential is higher than some critical level. At low ionic conditions, the electrostatic repulsive interaction along ssDNA becomes dominant, and ssDNA can be regarded as a model polyelectrolytes. Our MC simulation results suggested an exponential relation between external force and the total extension. This prediction was confirmed experimentally.
源文献作者	UNIV TSINGHUA
会议录	PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON FRONTIERS OF SCIENCE
会议录出版者	WORLD SCIENTIFIC PUBL CO PTE LTD
会议录出版地	SINGAPORE
语种	英语
ISBN号	981-238-407-3
WOS研究方向	Physics
内容类型	会议论文
源URL	[http://ir.itp.ac.cn/handle/311006/23729]
专题	SCI会议论文
作者单位	Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Ou-Yang, ZC,Zhou, H,Mang, Y. The elastic theory of a single DNA molecule[C]. 见:. UNIV TSINGHUA, BEIJING, PEOPLES R CHINA. JUN 16-19, 2002.