The stability of spherocyte membranes: Theoretical study

doi:10.1209/0295-5075/128/38001

CORC > 理论物理研究所 > 中国科学院理论物理研究所 > 理论物理所科研产出 > 理论物理所1978-2010年知识产出

	The stability of spherocyte membranes: Theoretical study
	Mu, W.; Ou-Yang, Z-C.; Cao, J.
刊名	EPL
	2019
卷号	128 期号:3 页码:38001
关键词	RED-BLOOD-CELLS MECHANICS FLUCTUATIONS CYTOSKELETON DEFORMATION ELASTICITY DYNAMICS MALARIA SHAPE
ISSN号	0295-5075
DOI	10.1209/0295-5075/128/38001
英文摘要	Human red blood cell (RBC) membranes are typically biconcave-shaped under physiological conditions, and membranes of other shapes, such as spherical, are also observed in pathological RBCs. It has been suggested that there is a relationship between the RBC membrane's material properties, morphologies and physiological functions. The present work studies how various factors affect the morphologies of the RBC membrane based on a free energy functional in continuum elasticity descriptions. In particular, the instability conditions of a diseased spherocyte's spherical shape is obtained explicitly, which determines the region in the phase diagram constructed by two dimensionless state variables defined by elastic moduli, osmotic pressure, etc., in which the spherocyte's membrane can exist in a stable form. In this phase diagram, each point represents the statistical results for a large number of samples observed in recent experiments. Within this stable region of spherocyte's membrane, the spherical RBC membrane is in the global minimal state whereas in the adjacent region on the other side of the boundary, the echinocyte's membrane corresponds to the global minimal state. Our results could be used as a theoretical guide for clinical applications in related diseases, such as malaria, and are in quantitative agreement with recent dynamic optical measurements on the morphological transition of the RBC membrane (see Park Y. et al. Proc. Natl. Acad. Sci. U.S.A., 107 (2010) 6731). Copyright (C) EPLA, 2020
学科主题	Physics
语种	英语
内容类型	期刊论文
源URL	[http://ir.itp.ac.cn/handle/311006/27114]
专题	理论物理研究所_理论物理所1978-2010年知识产出
作者单位	1.[Cao, J.] MIT, Dept Chem, Cambridge, MA 02139 USA 2.[Mu, W.] Wenzhou Med Univ, Sch Biomed Engn, Eye Hosp, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China 3.[Mu, W.] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Peoples R China 4.[Mu, W.] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA 5.[Ou-Yang, Z-C.] Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China 6.[Cao, J.] Singapore MIT Alliance Res & Technol SMART, Singapore 138602, Singapore
推荐引用方式 GB/T 7714	Mu, W.,Ou-Yang, Z-C.,Cao, J.. The stability of spherocyte membranes: Theoretical study[J]. EPL,2019,128(3):38001.
APA	Mu, W.,Ou-Yang, Z-C.,&Cao, J..(2019).The stability of spherocyte membranes: Theoretical study.EPL,128(3),38001.
MLA	Mu, W.,et al."The stability of spherocyte membranes: Theoretical study".EPL 128.3(2019):38001.