In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction

doi:10.1038/s42003-020-01400-7

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	In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction
	Wu, Jingyao 1; Mady, Leila J.2; Roy, Abhijit 1; Aral, Ali Mubin 3; Lee, Boeun 1; Zheng, Feng 4; Catalin, Toma 5,6; Chun, Youngjae 1,6,7; Wagner, William R.1,3,6,8; Yang, Ke
刊名	COMMUNICATIONS BIOLOGY
	2020-12-18
卷号	3 期号:1 页码:11
DOI	10.1038/s42003-020-01400-7
通讯作者	Kumta, Prashant N.(pkumta@pitt.edu)
英文摘要	Pediatric laryngotracheal stenosis is a complex congenital or acquired airway injury that may manifest into a potentially life-threatening airway emergency condition. Depending on the severity of obstruction, treatment often requires a combination of endoscopic techniques, open surgical repair, intraluminal stenting, or tracheostomy. A balloon expandable biodegradable airway stent maintaining patency while safely degrading over time may address the complications and morbidity issues of existing treatments providing a less invasive and more effective management technique. Previous studies have focused on implementation of degradable polymeric scaffolds associated with potentially life-threatening pitfalls. The feasibility of an ultra-high ductility magnesium-alloy based biodegradable airway stents was demonstrated for the first time. The stents were highly corrosion resistant under in vitro flow environments, while safely degrading in vivo without affecting growth of the rabbit airway. The metallic matrix and degradation products were well tolerated by the airway tissue without exhibiting any noticeable local or systemic toxicity. Wu et al. demonstrate utility of a novel, ultrahigh ductility Mg alloy-based biodegradable stent in vitro and in vivo for use in congenital disorders like pediatric laryngotracheal stenosis. Tested in both bioreactor system and rabbit airway model, these stents display higher corrosion resistance and better in vivo degradation without affecting growth of rabbit airway.
资助项目	NSF[EEC-0812348] ; National Science Foundation[CBET-0933153] ; Edward R. Weidlein Chair Professorship Funds ; Center for Complex Engineered Multifunctional Materials (CCEMM) at the Swanson School of Engineering in the University of Pittsburgh
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000608502100002
资助机构	NSF ; National Science Foundation ; Edward R. Weidlein Chair Professorship Funds ; Center for Complex Engineered Multifunctional Materials (CCEMM) at the Swanson School of Engineering in the University of Pittsburgh
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/158948]
专题	金属研究所_中国科学院金属研究所
通讯作者	Kumta, Prashant N.
作者单位	1.Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15261 USA 2.Univ Pittsburgh, Dept Otolaryngol, Pittsburgh, PA 15261 USA 3.Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15261 USA 4.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 5.Univ Pittsburgh, Med Ctr, Heart & Vasc Inst, Pittsburgh, PA 15261 USA 6.McGowan Inst Regenerat Med, Pittsburgh, PA 15261 USA 7.Univ Pittsburgh, Dept Ind Engn, Pittsburgh, PA 15261 USA 8.Univ Pittsburgh, Dept Chem & Petr Engn, Pittsburgh, PA 15261 USA 9.Univ Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA 15213 USA 10.Childrens Hosp Pittsburgh UPMC, Dept Otolaryngol, Pittsburgh, PA 15224 USA
推荐引用方式 GB/T 7714	Wu, Jingyao,Mady, Leila J.,Roy, Abhijit,et al. In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction[J]. COMMUNICATIONS BIOLOGY,2020,3(1):11.
APA	Wu, Jingyao.,Mady, Leila J..,Roy, Abhijit.,Aral, Ali Mubin.,Lee, Boeun.,...&Kumta, Prashant N..(2020).In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction.COMMUNICATIONS BIOLOGY,3(1),11.
MLA	Wu, Jingyao,et al."In-vivo efficacy of biodegradable ultrahigh ductility Mg-Li-Zn alloy tracheal stents for pediatric airway obstruction".COMMUNICATIONS BIOLOGY 3.1(2020):11.