Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system

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	Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system
	Li Zhaoyang; Du Bing; Li Shengyang; Lv Xiangchuan; Zhou Shenglai; Yu Yang; Wang Wei; Zheng Zhihong
刊名	NEURAL REGENERATION RESEARCH
	2013
卷号	8 期号:2 页码:156-U97
关键词	LIPOPROTEIN-LIPASE TRANSCRIPTION FACTORS GENETIC ASSOCIATION EXPRESSION JUN DEFICIENCY ACTIVATION NEURONS DISEASE METABOLISM neural regeneration basic research apolipoprotein C2 promoter dual-luciferase reporter assay transcriptional activity regulatory elements grants-supported paper neuroregeneration
ISSN号	1673-5374
其他题名	Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system ★
英文摘要	Apolipoprotein C2 is an important member of the apolipoprotein C family, and is a potent activator of lipoprotein lipase. In the central nervous system, apolipoprotein C2 plays an important role in the catabolism of triglyceride-rich lipoproteins. Studies into the exact regulatory mechanism of mouse apolipoprotein C2 expression have not been reported. In this study, seven luciferase expression vectors, which contained potential mouse apolipoprotein C2 gene promoters, were constructed and co-transfected with pRL-TK into HEK293T cells to investigate apolipoprotein C2 promoter activity. Luciferase assays indicated that the apolipoprotein C2 promoter region was mainly located in the +104 bp to +470 bp region. The activity of the different lengths of apolipoprotein C2 promoter region varied. This staggered negative-positive-negative arrangement indicates the complex regulation of apolipoprotein C2 expression and provides important clues for elucidating the regulatory mechanism of apolipoprotein C2 gene transcription.
资助项目	[National Natural Science Foundation of China] ; [Education Department of Liaoning Province]
语种	英语
CSCD记录号	CSCD:4753407
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/153728]
专题	金属研究所_中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Li Zhaoyang,Du Bing,Li Shengyang,et al. Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system[J]. NEURAL REGENERATION RESEARCH,2013,8(2):156-U97.
APA	Li Zhaoyang.,Du Bing.,Li Shengyang.,Lv Xiangchuan.,Zhou Shenglai.,...&Zheng Zhihong.(2013).Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system.NEURAL REGENERATION RESEARCH,8(2),156-U97.
MLA	Li Zhaoyang,et al."Cloning and characterization of an apolipoprotein C2 promoter in the mouse central nervous system".NEURAL REGENERATION RESEARCH 8.2(2013):156-U97.