An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants

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	An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants
	Cao Minjie 5; Liu Xue 5; Zhang Yan 4; Xue Xiaoqian 4; Zhou X Edward 2; Melcher Karsten 2; Gao Pan 5; Wang Fuxing 5; Zeng Liang 5; Zhao Yang 1
刊名	CELL RESEARCH
	2013
卷号	23 期号:8 页码:1043-1054
关键词	ABSCISIC-ACID ARABIDOPSIS MECHANISM PHOSPHATASES SOFTWARE PROTEINS KINASES STRESS GENE abscisic acid plant hormone drought resistance crystal structure ABA-mimicking ligand
ISSN号	1001-0602
其他题名	An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants
英文摘要	Abscisic acid (ABA) is the most important hormone for plants to resist drought and other abiotic stresses. ABA binds directly to the PYR/PYL family of ABA receptors, resulting in inhibition of type 2C phosphatases (PP2C) and activation of downstream ABA signaling. It is envisioned that intervention of ABA signaling by small molecules could help plants to overcome abiotic stresses such as drought, cold and soil salinity. However, chemical instability and rapid catabolism by plant enzymes limit the practical application of ABA itself. Here we report the identification of a small molecule ABA mimic (AM1) that acts as a potent activator of multiple members of the family of ABA receptors. In Arabidopsis, AM1 activates a gene network that is highly similar to that induced by ABA. Treatments with AM1 inhibit seed germination, prevent leaf water loss, and promote drought resistance. We solved the crystal structure of AM1 in complex with the PYL2 ABA receptor and the HAB1 PP2C, which revealed that AM1 mediates a gate-latch-lock interacting network, a structural feature that is conserved in the ABA-bound receptor/PP2C complex. Together, these results demonstrate that a single small molecule ABA mimic can activate multiple ABA receptors and protect plants from water loss and drought stress. Moreover, the AM1 complex crystal structure provides a structural basis for designing the next generation of ABA-mimicking small molecules.
资助项目	[Jay and Betty Van Andel Foundation] ; [Amway (China)] ; [National Natural Science Foundation of China] ; [US National Institute of Health] ; [Chinese Academy of Sciences]
语种	英语
CSCD记录号	CSCD:4907353
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/152722]
专题	金属研究所_中国科学院金属研究所
作者单位	1.普渡大学 2.Van Andel Res Institute, Ctr Struct Biol & Drug Discovery, Lab Struct Sci, Grand Rapids, MI 49503 USA 3.中国科学院金属研究所 4.中国科学院 5.中国科学院上海植物逆境生物学研究中心
推荐引用方式 GB/T 7714	Cao Minjie,Liu Xue,Zhang Yan,et al. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants[J]. CELL RESEARCH,2013,23(8):1043-1054.
APA	Cao Minjie.,Liu Xue.,Zhang Yan.,Xue Xiaoqian.,Zhou X Edward.,...&Xu Yong.(2013).An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants.CELL RESEARCH,23(8),1043-1054.
MLA	Cao Minjie,et al."An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants".CELL RESEARCH 23.8(2013):1043-1054.