Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents | |
Meng Ying1; Wang Guan2; Li Yue1; Hou Kuan1; Yuan Yue1; Zhang LiJuan1; Song HongRui1; Shi Wei2 | |
刊名 | CHINESE CHEMICAL LETTERS
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2013 | |
卷号 | 24期号:7页码:619-621 |
关键词 | Pyrrolopyrazinone Antitumor Synthesis |
ISSN号 | 1001-8417 |
其他题名 | Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents |
英文摘要 | A series of pyrrolo1,2-apyrazinone compounds (5a-9f) were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MU method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed. (C) 2013 Hong-Rui Song and Wei Shi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
语种 | 英语 |
CSCD记录号 | CSCD:4904853 |
内容类型 | 期刊论文 |
源URL | [http://ir.imr.ac.cn/handle/321006/151510] ![]() |
专题 | 金属研究所_中国科学院金属研究所 |
作者单位 | 1.中国科学院金属研究所 2.吉林大学 |
推荐引用方式 GB/T 7714 | Meng Ying,Wang Guan,Li Yue,et al. Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents[J]. CHINESE CHEMICAL LETTERS,2013,24(7):619-621. |
APA | Meng Ying.,Wang Guan.,Li Yue.,Hou Kuan.,Yuan Yue.,...&Shi Wei.(2013).Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents.CHINESE CHEMICAL LETTERS,24(7),619-621. |
MLA | Meng Ying,et al."Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents".CHINESE CHEMICAL LETTERS 24.7(2013):619-621. |
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