Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

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	Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
	Meng Ying 1; Wang Guan 2; Li Yue 1; Hou Kuan 1; Yuan Yue 1; Zhang LiJuan 1; Song HongRui 1; Shi Wei 2
刊名	CHINESE CHEMICAL LETTERS
	2013
卷号	24 期号:7 页码:619-621
关键词	Pyrrolopyrazinone Antitumor Synthesis
ISSN号	1001-8417
其他题名	Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents
英文摘要	A series of pyrrolo1,2-apyrazinone compounds (5a-9f) were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MU method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed. (C) 2013 Hong-Rui Song and Wei Shi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
语种	英语
CSCD记录号	CSCD:4904853
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/151510]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.吉林大学
推荐引用方式 GB/T 7714	Meng Ying,Wang Guan,Li Yue,et al. Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents[J]. CHINESE CHEMICAL LETTERS,2013,24(7):619-621.
APA	Meng Ying.,Wang Guan.,Li Yue.,Hou Kuan.,Yuan Yue.,...&Shi Wei.(2013).Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents.CHINESE CHEMICAL LETTERS,24(7),619-621.
MLA	Meng Ying,et al."Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents".CHINESE CHEMICAL LETTERS 24.7(2013):619-621.