Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury

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	Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury
	Fan Hongjie; Yu Weidong; Wang Zongli; Wang Qian; He Zhiyi
刊名	NEURAL REGENERATION RESEARCH
	2010
卷号	5 期号:17 页码:1296-1302
关键词	STROMAL CELLS ARTERY OCCLUSION RAT MODEL ISCHEMIA BRAIN TRANSPLANTATION STROKE APOPTOSIS DIFFERENTIATION EXPRESSION bone marrow-derived mesenchymal stem cells cerebral ischemia/reperfusion survivin caspase-3 cell apoptosis brain injury neural regeneration
ISSN号	1673-5374
其他题名	Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury
英文摘要	The time point at which bone marrow-derived mesenchymal stem cells (BMSCs) can be used in transplantation for the treatment of ischemic brain injury remains unclear. In the present study, BMSCs were transplanted to the ischemic site 90 minutes post-ischemia. The results demonstrated that the transplanted BMSCs improved neurological function, reduced infarct volume, increased survivin expression, decreased caspase-3 expression and reduced apoptosis. This suggests that BMSCs transplanted at an ultra-early stage ameliorated brain ischemia by increasing survivin expression, decreasing caspase-3 expression and reducing apoptosis at the ischemia/reperfusion injury site.
资助项目	[Cancer of Larynx, Department of Equipment, First Hospital of China Medical University] ; [Liaoning Provincial Education Department]
语种	英语
CSCD记录号	CSCD:4041464
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/151307]
专题	金属研究所_中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Fan Hongjie,Yu Weidong,Wang Zongli,et al. Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury[J]. NEURAL REGENERATION RESEARCH,2010,5(17):1296-1302.
APA	Fan Hongjie,Yu Weidong,Wang Zongli,Wang Qian,&He Zhiyi.(2010).Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury.NEURAL REGENERATION RESEARCH,5(17),1296-1302.
MLA	Fan Hongjie,et al."Ultra-early treatment of bone marrow-derived mesenchymal stem cells for focal cerebral ischemia/reperfusion injury".NEURAL REGENERATION RESEARCH 5.17(2010):1296-1302.