Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air

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	Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air
	Yin Lu 1; Jia Xian 1; Li Xing Shu 2; Chan Albert S C 1
刊名	CHINESE CHEMICAL LETTERS
	2010
卷号	21 期号:7 页码:774-777
关键词	RACEMIC SECONDARY ALCOHOLS RECOMBINANT ESCHERICHIA-COLI CHIRAL NHC-PD(II) COMPLEXES ALPHA-HYDROXY ESTERS AEROBIC OXIDATION MOLECULAR-OXYGEN SALEN COMPLEXES (R)-O-CHLOROMANDELATE (-)-SPARTEINE MODEL Ambient air Vanadium-catalyzed OKR Methyl o-chloromandelate Schiff base ligands
ISSN号	1001-8417
其他题名	Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air
英文摘要	Vanadium-catalyzed oxidative kinetic resolution (OKR) of methyl o-chloromandelate 2a, key intermediate of the well-known oral antiplatelet agent (S)-clopidogrel, was achieved by ambient air for the first time. The air oxidation system, which was composed of vanadium and tridentate Schiff base ligands derived from amino alcohols and salicylaldehyde derivatives, afforded an efficient and economic approach to the target intermediate with high enantioselectivities (>99% ee). (C) 2010 Xian Jia. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
资助项目	[National Natural Science Foundation of China] ; [Ministry of Education]
语种	英语
CSCD记录号	CSCD:3924935
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/151115]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.中国科学院广州地球化学研究所
推荐引用方式 GB/T 7714	Yin Lu,Jia Xian,Li Xing Shu,et al. Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air[J]. CHINESE CHEMICAL LETTERS,2010,21(7):774-777.
APA	Yin Lu,Jia Xian,Li Xing Shu,&Chan Albert S C.(2010).Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air.CHINESE CHEMICAL LETTERS,21(7),774-777.
MLA	Yin Lu,et al."Simply air: Vanadium-catalyzed oxidative kinetic resolution of methyl o-chloromandelate by ambient air".CHINESE CHEMICAL LETTERS 21.7(2010):774-777.