Expressions of Livin and Smac proteins in non-small cell lung cancer

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	Expressions of Livin and Smac proteins in non-small cell lung cancer
	Yang Chunlu 2; Chen Xiao 2; Zhao Jun 2; Lan Xingang 2; Xu Sun 2; Zhang Huan 1; Han Libo 2; Zhang Lin 2
刊名	CHINESE JOURNAL OF CANCER RESEARCH
	2008
卷号	20 期号:2 页码:144-149
关键词	ML-IAP APOPTOSIS INHIBITOR FAMILY GENE SURVIVIN MEMBER TARGET non-small cell lung cancer Livin Smac lymph node metastasis prognosis immunohistochemistry
ISSN号	1000-9604
其他题名	Expressions of Livin and Smac proteins in non-small cell lung cancer
英文摘要	Objective: To investigate the expression characteristics of Livin and second mitochondrial activator of Caspase (Smac) proteins in non-small cell lung cancer (NSCLC), and analyze their effect on patients' prognosis. Methods: The expressions of Livin and Smac proteins were detected in 89 NSCLC tissue samples and 25 normal lung tissue samples by immunohistochemical technique. Results: The positive expression rates of Livin and Smac proteins in NSCLC tissues were 53.9%, and 58.4% respectively, higher than that in normal lung tissues (P 0.05). The expression level of Smac protein was closely related to lymph node metastasis, TNM stage (P 0.05). Kaplan-Meier analysis revealed a significant impact on survival by Livin protein in NSCLC (P 0.05). Conclusions: Overexpression of Livin protein may play a promoting role in the occurrence and progression of NSCLC. Moreover, it may bring an adverse effect on patients' prognosis. Although overexpression of Smac protein affects the occurrence and progression of NSCLC, it has no relationship with the prognosis. Livin protein may be helpful to evaluate the progression of NSCLC, and to predict the prognosis.
语种	英语
CSCD记录号	CSCD:3299657
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/150339]
专题	金属研究所_中国科学院金属研究所
作者单位	1.MCH Hosp Tanggu Dist, Ctr Ultrasound, Tianjin 300451, Peoples R China 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Yang Chunlu,Chen Xiao,Zhao Jun,et al. Expressions of Livin and Smac proteins in non-small cell lung cancer[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(2):144-149.
APA	Yang Chunlu.,Chen Xiao.,Zhao Jun.,Lan Xingang.,Xu Sun.,...&Zhang Lin.(2008).Expressions of Livin and Smac proteins in non-small cell lung cancer.CHINESE JOURNAL OF CANCER RESEARCH,20(2),144-149.
MLA	Yang Chunlu,et al."Expressions of Livin and Smac proteins in non-small cell lung cancer".CHINESE JOURNAL OF CANCER RESEARCH 20.2(2008):144-149.