Expression of SKP2 protein in lung carcinoma

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	Expression of SKP2 protein in lung carcinoma
	Zhao Jun 1; Yang Chunlu 1; Zhang Huan 2; Ding Weizhong 1; Liu Zhiping 1; Liu Jingyi 1
刊名	CHINESE JOURNAL OF CANCER RESEARCH
	2008
卷号	20 期号:3 页码:216-221
关键词	S-PHASE KINASE DOWN-REGULATION CANCER CELLS GENE OVEREXPRESSION RNA P27 ADENOCARCINOMA AMPLIFICATION DEGRADATION lung carcinoma SKP2 protein Tissue Chip Immunohistochemistry
ISSN号	1000-9604
其他题名	Expression of SKP2 protein in lung carcinoma
英文摘要	Objective: To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods: The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results: The positive rate of SKP2 protein staining was (23.52 +/- 13.57)% in non small cell lung carcinoma and (53.85 +/- 12.26)% in small cell lung carcinoma, which were significantly higher than (2.91 +/- 1.27)% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them (P=0.000). The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group (P-1=0.003/0.002; r=-0.275, P-2=0.005). Conclusion: The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.
语种	英语
CSCD记录号	CSCD:3360145
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/148696]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.MCH Hosp Tanggu Dist Tianjin City, Ctr Supersound, Tianjin 300451, Peoples R China
推荐引用方式 GB/T 7714	Zhao Jun,Yang Chunlu,Zhang Huan,et al. Expression of SKP2 protein in lung carcinoma[J]. CHINESE JOURNAL OF CANCER RESEARCH,2008,20(3):216-221.
APA	Zhao Jun,Yang Chunlu,Zhang Huan,Ding Weizhong,Liu Zhiping,&Liu Jingyi.(2008).Expression of SKP2 protein in lung carcinoma.CHINESE JOURNAL OF CANCER RESEARCH,20(3),216-221.
MLA	Zhao Jun,et al."Expression of SKP2 protein in lung carcinoma".CHINESE JOURNAL OF CANCER RESEARCH 20.3(2008):216-221.