Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed Multiple Myeloma Patients: A Multicenter Study in China

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	Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed Multiple Myeloma Patients: A Multicenter Study in China
	Zhong YuPing 2; Zhang YiZhuo 3; Liao AiJun 4; Lil SuXia 5; Tian Chen 1; Lu Jin 6
刊名	Chinese Medical Journal
	2017
卷号	130 期号:2 页码:130-134
关键词	Geriatric Assessment Medicine R Multicenter Study Multiple Myeloma
ISSN号	0366-6999
其他题名	Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed Multiple Myeloma Patients: A Multicenter Study in China
英文摘要	Background: Elderly multiple myeloma (MM) patients often tend to suffer a variety of diseases, so the treatment of choice is very difficult for the elderly myeloma patients. The overall survival (OS) time and side effects with elderly patients are unclear in China. The study tried to find out the role of geriatric assessment in the Chinese elderly MM. Methods: We retrospectively analyzed the data of 628 newly diagnosed patients from six hospitals from June 2011 to June 2013. A geriatric assessment had been performed to assess comorbidities, cognitive, and physical status for these patients. The primary endpoint was to evaluate different physical states of elderly patients with OS time and treatment-related side effects. Results: An additive scoring system (range: 0-5), based on age, Katz′s Activity of Daily Living (ADL) and Lawton′s Instrumental Activity of Daily Living (IADL) ≤5 and Charlson Comorbidity Index (CCI) was developed to identify three groups: fit (score = 0); intermediate-fitness (score = 1); and frail (score ≥2). The 3-year OS was 63% in fit patients, 63% in intermediate-fitness patients, and 49% in frail patients ≥3 hematologic adverse events (AEs) were documented in 45 (35.4%) fit, 34 (34%) intermediate-fitness, and 121 (30.2%) frail patients. The risk of a grade ≥3 hematologic AEs was not significantly increase in intermediate-fitness (hazard ratios HR: 0.99, 95% confidence interval CI: 0.54-1.47, P = 1.000) and in frail patients (HR: 1.16, 95% CI: 0.70-1.93, P = 0.558) compared with fit ones. Conclusions: MM occurs earlier in life and being advanced when the diagnosis is made in the mainland of China. The overall survival in frailty with International Staging System (ISS) II/III was the worst in all patients.
资助项目	[National Natural Science Foundation of China]
语种	英语
CSCD记录号	CSCD:5900084
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/148193]
专题	金属研究所_中国科学院金属研究所
作者单位	1.Peoples Liberat Army 304 Hosp, Department Hematol, Beijing 100048, Peoples R China 2.Beijing Univ, Clin Res Institute, Capital Med Univ, Dept Hematol,Beijing Chaoyang Hosp West, Beijing 100043, Peoples R China 3.中国科学院合肥物质科学研究院肿瘤医院 4.中国科学院金属研究所 5.Peoples Liberat Army 301 Hosp, Department Hematol, Beijing 100853, Peoples R China 6.北京大学
推荐引用方式 GB/T 7714	Zhong YuPing,Zhang YiZhuo,Liao AiJun,et al. Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed Multiple Myeloma Patients: A Multicenter Study in China[J]. Chinese Medical Journal,2017,130(2):130-134.
APA	Zhong YuPing,Zhang YiZhuo,Liao AiJun,Lil SuXia,Tian Chen,&Lu Jin.(2017).Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed Multiple Myeloma Patients: A Multicenter Study in China.Chinese Medical Journal,130(2),130-134.
MLA	Zhong YuPing,et al."Geriatric Assessment to Predict Survival and Risk of Serious Adverse Events in Elderly Newly Diagnosed Multiple Myeloma Patients: A Multicenter Study in China".Chinese Medical Journal 130.2(2017):130-134.