Gold nanoparticles for high-throughput genotyping of long-range haplotypes

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	Gold nanoparticles for high-throughput genotyping of long-range haplotypes
	Chen, P ; Pan, D（潘敦） ; Fan, CH（樊春海） ; Chen, JH ; Huang, K ; Wang, DF ; Zhang, HL ; Li, Y ; Feng, GY ; Liang, PJ ; He, L ; Shi, YY
刊名	NATURE NANOTECHNOLOGY
	2011
卷号	6 期号:10 页码:639
ISSN号	1748-3387
英文摘要	Completion of the Human Genome Project(1) and the HapMap Project(2) has led to increasing demands for mapping complex traits in humans to understand the aetiology of diseases(3). Identifying variations in the DNA sequence, which affect how we develop disease and respond to pathogens and drugs, is important for this purpose, but it is difficult to identify these variations in large sample sets(3-5). Here we show that through a combination of capillary sequencing and polymerase chain reaction assisted by gold nanoparticles, it is possible to identify several DNA variations that are associated with age-related macular degeneration(6-8) and psoriasis(9) on significant regions of human genomic DNA. Our method is accurate and promising for large-scale and high-throughput genetic analysis of susceptibility towards disease and drug resistance(10-12).
收录类别	SCI
语种	英语
WOS记录号	WOS:000295923800012
公开日期	2013-09-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/12863]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Chen, P,Pan, D,Fan, CH,et al. Gold nanoparticles for high-throughput genotyping of long-range haplotypes[J]. NATURE NANOTECHNOLOGY,2011,6(10):639.
APA	Chen, P.,Pan, D.,Fan, CH.,Chen, JH.,Huang, K.,...&Shi, YY.(2011).Gold nanoparticles for high-throughput genotyping of long-range haplotypes.NATURE NANOTECHNOLOGY,6(10),639.
MLA	Chen, P,et al."Gold nanoparticles for high-throughput genotyping of long-range haplotypes".NATURE NANOTECHNOLOGY 6.10(2011):639.