Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray

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	Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray
	Zhang Shuguang 2; Li Fang 3; Li Wenya 2; Lu Wei 2; Zhang Lin 2
刊名	CHINESE JOURNAL OF CANCER RESEARCH
	2007
卷号	19 期号:1 页码:7-11
关键词	TERNARY COMPLEX FACTORS TRANSCRIPTION FACTORS ETS Elk-1 non-small cell lung cancer western blot immunohistochemistry tissue microarray
ISSN号	1000-9604
其他题名	Expression of Elk-1 in Non-Small Cell Lung Cancer Detected by Western Blot and Tissue Microarray
英文摘要	Objective: The aim of this study was to investigate the Elk- 1 ( Ets like transcription factor- 1) expression in non- small cell lung cancer ( NSCLC) and normal lung tissues and the relationship between its expression and clinicopathological characters. Methods: To observe Elk- 1 expression, western blot and immunochemistry ( IHC) on tissue microarray ( TMA) containing 118 lung cancers and their corresponding normal tissues were used. Results: In western blot and IHC on TMA, Elk- 1 was highly expressed in NSCLC, while its expression was almost undetectable in normal lung tissues. Elk- 1 expression in NSCLC had no relationship with the patients' age, gender, smoking status and histological type, but had relationship with the differentiation degree, clinical stages and lymphonode metastasis. The expression was lower in early stage group ( I+ II) than in advanced stage group ( III), and lower in well- moderately differentiated group than in poorly differentiated group. The same trend was seen with lymphonode metastasis. Conclusion: The progression of NSCLC may be related with the increased Elk- 1 expression, and Elk- 1 may be regarded as a prognostic factor for NSCLC tissues.
语种	英语
CSCD记录号	CSCD:2920359
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/147427]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国医学科学院 2.中国科学院金属研究所 3.Chinese Acad Med Sci, Dept Thorac Surg, Institute Canc, Beijing 100021, Peoples R China Dept Thorac Surg Institute Canc 4.Peking Union Med Coll, Beijing 100021, Peoples R China
推荐引用方式 GB/T 7714	Zhang Shuguang,Li Fang,Li Wenya,et al. Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(1):7-11.
APA	Zhang Shuguang,Li Fang,Li Wenya,Lu Wei,&Zhang Lin.(2007).Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray.CHINESE JOURNAL OF CANCER RESEARCH,19(1),7-11.
MLA	Zhang Shuguang,et al."Expression of Elk-1 in non-small cell lung cancer detected by western blot and tissue microarray".CHINESE JOURNAL OF CANCER RESEARCH 19.1(2007):7-11.