Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers

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	Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers
	Wan, Y ; Deng, WP ; Su, Y ; Zhu, XH ; Peng, C（彭程） ; Hu, HY ; Peng, HZ（彭红珍） ; Song, SP（宋世平） ; Fan, CH（樊春海）
刊名	BIOSENSORS & BIOELECTRONICS
	2011
卷号	30 期号:1 页码:93
ISSN号	0956-5663
英文摘要	A multiplexing electrochemical immunosensor was developed for ultrasensitive detection of cancer related protein biomarkers. We employed disposable screen-printed carbon electrode (SPCE) array as the detection platform. A universal multi-labeled nanoprobe was developed by loading HRP and goat-anti-rabbit IgG (secondary antibody, Ab(2)) onto multiwalled carbon nanotube (MWNT). This universal nanoprobe was available for virtually any sandwich-based antigen detection and showed superiority in several areas. By using the SPCE array and the universal nanoprobe, we could detect as low as 5 pg mL(-1) of prostate specific antigen (PSA) and 8 pg mL(-1) of Interleukin 8 (IL-8) with the electrochemical immunosensor. We also demonstrated simultaneous detection of two protein biomarkers with this platform. With these attracted features, our immunoassay system shows promising applications for in-field and point-of-care test in clinical diagnostics. (C) 2011 Elsevier B.V. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000297610200014
公开日期	2013-09-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/12848]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wan, Y,Deng, WP,Su, Y,et al. Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers[J]. BIOSENSORS & BIOELECTRONICS,2011,30(1):93.
APA	Wan, Y.,Deng, WP.,Su, Y.,Zhu, XH.,Peng, C.,...&Fan, CH.(2011).Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers.BIOSENSORS & BIOELECTRONICS,30(1),93.
MLA	Wan, Y,et al."Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers".BIOSENSORS & BIOELECTRONICS 30.1(2011):93.