Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca2+ levels

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	Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca2+ levels
	Gai Xiangyun 2; Wei Yuhai 3; Zhang Wei 1; Wuren Tana 1; Wang Yaping 1; Li Zhanqiang 1; Liu Shou 1; Ma Lan 1; Lu Dianxiang 1; Zhou Yi 2
刊名	ACTA PHARMACOLOGICA SINICA
	2015
卷号	36 期号:5 页码:587-596
关键词	ACTIVATED POTASSIUM CHANNELS K+ CHANNELS CALCIUM-CHANNEL Tibetan herb echinacoside pulmonary hypertension high altitude vasorelaxation NO BKCa K-IR artery ring pulmonary arterial smooth muscle cells
ISSN号	1671-4083
其他题名	Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BK Ca channels and reducing intracellular Ca 2+ levels
英文摘要	Aim: Sustained pulmonary vasoconstriction as experienced at high altitude can lead to pulmonary hypertension (PH). The main purpose of this study is to investigate the vasorelaxant effect of echinacoside (ECH), a phenylethanoid glycoside from the Tibetan herb Lagotis brevituba Maxim and Cistanche tubulosa, on the pulmonary artery and its potential mechanism.
资助项目	[National Program on Key Basic Research Project of China] ; [Program of International Science and Technology Cooperation of China] ; [National Natural Science Foundation of China] ; [Key Laboratories Development Program of Qinghai Province] ; [Qinghai-Utah Joint Research Key Lab for High Altitude Medicine] ; [Ministry of Education New Century Outstanding Talents Support Program of China] ; [Natural Science Foundation of Qinghai]
语种	英语
CSCD记录号	CSCD:5425432
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/143844]
专题	金属研究所_中国科学院金属研究所
作者单位	1.青海大学 2.中国科学院金属研究所 3.Qinghai Entry Exit Inspect & Quarantine Bur, Xining 810001, Peoples R China
推荐引用方式 GB/T 7714	Gai Xiangyun,Wei Yuhai,Zhang Wei,et al. Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca2+ levels[J]. ACTA PHARMACOLOGICA SINICA,2015,36(5):587-596.
APA	Gai Xiangyun.,Wei Yuhai.,Zhang Wei.,Wuren Tana.,Wang Yaping.,...&Ge Rili.(2015).Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca2+ levels.ACTA PHARMACOLOGICA SINICA,36(5),587-596.
MLA	Gai Xiangyun,et al."Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca2+ levels".ACTA PHARMACOLOGICA SINICA 36.5(2015):587-596.