Melatonin lowers edema after spinal cord injury

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	Melatonin lowers edema after spinal cord injury
	Li Cheng 1; Chen Xiao 1; Qiaol Suchi 1; Liu Xinwei 2; Liu Chang 1; Zhu Degang 1; Su Jiacan 1; Wang Zhiwei 1
刊名	NEURAL REGENERATION RESEARCH
	2014
卷号	9 期号:24 页码:2205-2210
关键词	RANDOMIZED CONTROLLED-TRIAL AQUAPORIN-4 EXPRESSION TIRILAZAD MESYLATE SECONDARY INJURY ISCHEMIC-INJURY NEURONAL DEATH WATER CHANNELS BRAIN EDEMA METHYLPREDNISOLONE RATS nerve regeneration spinal cord injury melatonin edema aquaporin glial fibrillary acidic protein immunohistochemistry western blot assay neural regeneration
ISSN号	1673-5374
其他题名	Melatonin lowers edema after spinal cord injury
英文摘要	Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein.
资助项目	[China Postdoctoral Science Foundation Grant]
语种	英语
CSCD记录号	CSCD:5325093
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/142272]
专题	金属研究所_中国科学院金属研究所
作者单位	1.Second Mil Med University, Changhai Hosp, Dept Orthoped Surg, Shanghai 200433, Peoples R China 2.中国科学院金属研究所
推荐引用方式 GB/T 7714	Li Cheng,Chen Xiao,Qiaol Suchi,et al. Melatonin lowers edema after spinal cord injury[J]. NEURAL REGENERATION RESEARCH,2014,9(24):2205-2210.
APA	Li Cheng.,Chen Xiao.,Qiaol Suchi.,Liu Xinwei.,Liu Chang.,...&Wang Zhiwei.(2014).Melatonin lowers edema after spinal cord injury.NEURAL REGENERATION RESEARCH,9(24),2205-2210.
MLA	Li Cheng,et al."Melatonin lowers edema after spinal cord injury".NEURAL REGENERATION RESEARCH 9.24(2014):2205-2210.