Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system

doi:10.1016/j.carbpol.2018.06.058

CORC > 金属研究所 > 中国科学院金属研究所

	Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system
	Lv, Xiaojie 1,3; Zhang, Wenchang 1; Liu, Yunen 2; Zhao, Yan 1; Zhang, Jinsong 1; Hou, Mingxiao 2
刊名	CARBOHYDRATE POLYMERS
	2018-10-15
卷号	198 页码:86-93
关键词	Polyelectrolyte complex hydrogels pH-sensitive Superabsorbent Electrostatic Interactions Oral drug delivery
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2018.06.058
通讯作者	Zhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jshzhang@imr.ac.cn)
英文摘要	Polyelectrolyte complex (PECs) hydrogels with high hygroscopicity modulation ability were successfully prepared based on carboxymethyl chitosan (CMCS)/alginate. The swelling ratio of the hydrogels could be tuned from 1 to 450 simply by changing the weight ratio of CMCS to alginate, and superabsorbent hydrogels were obtained when the weight ratio of CMCS to alginate was below 1/1. Also, the swelling kinetics and water diffusion mechanism in the hydrogels were discussed. In vitro cytotoxicity results indicated that hydrogels had excellent cytocompatibility. The swelling ratio of the hydrogel as well as its BSA releasing profile was notably pH dependent. Compared with the values at pH 1.2, the swelling ratio of hydrogels (CMCS/alginate weight ratio of 1/2) at pH 7.4 was about 34 times higher, and the amount of BSA released at pH 7.4 was also significantly higher. The as-prepared CMCS/alginate PECs hydrogels hold great potential for oral delivery of protein drugs through the intestinal tract.
资助项目	National Key Research and Development Plan[2016YFB0301502] ; National Natural Science Foundation of China[U1608255]
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000440785200011
资助机构	National Key Research and Development Plan ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/129002]
专题	金属研究所_中国科学院金属研究所
通讯作者	Zhao, Yan; Zhang, Jinsong
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Gen Hosp Shenyang Mil Command, Dept Emergency Med, Shenyang 110016, Liaoning, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,et al. Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system[J]. CARBOHYDRATE POLYMERS,2018,198:86-93.
APA	Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,Zhao, Yan,Zhang, Jinsong,&Hou, Mingxiao.(2018).Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system.CARBOHYDRATE POLYMERS,198,86-93.
MLA	Lv, Xiaojie,et al."Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system".CARBOHYDRATE POLYMERS 198(2018):86-93.