In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect

doi:10.1080/10667857.2018.1452587

CORC > 金属研究所 > 中国科学院金属研究所

	In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect
	Dong, Jiahui 1,2; Tan, Lili 1; Yang, Jiahui 3; Wang, Yongxuan 3; Chen, Junxiu 1,2; Wang, Weidan 1; Zhao, Dewei 3; Yang, Ke 1
刊名	MATERIALS TECHNOLOGY
	2018
卷号	33 期号:6 页码:387-397
关键词	Mg-Sr alloy bone defect heat treatment bone response
ISSN号	1066-7857
DOI	10.1080/10667857.2018.1452587
通讯作者	Tan, Lili(lltan@imr.ac.cn) ; Zhao, Dewei(zhaodewei2000@163.com)
英文摘要	Mg-Sr alloy is considered as a promising biodegradable bone repair material. However, its poor corrosion resistance limits its clinical application. In this study, the corrosion rate of Mg-Sr alloy was greatly improved through the heat treatment. Both in vitro and in vivo corrosion tests (immersion and electrochemical test) showed that corrosion resistance of Mg-Sr alloy was enhanced. In the animal test (New Zealand rabbit), both micro-CT analysis and Van Gieson staining demonstrated that the treated Mg-Sr alloy implant exhibited better osteogenesis and osteointegration ability, which accelerate the healing of bone defect. The results indicate that the treated Mg-Sr alloy has great possibility and potential for application as a new bone repair material.
资助项目	Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1101804] ; Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement[2016YFC1100604] ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials ; National Natural Science Foundation of China[31500777] ; Institute of Metal Research, Chinese Academy of Sciences[2015-ZD01]
WOS研究方向	Materials Science
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000430487300001
资助机构	Key Program of China on Biomedical Materials Research and Tissue and Organ Replacement ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials ; National Natural Science Foundation of China ; Institute of Metal Research, Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/127770]
专题	金属研究所_中国科学院金属研究所
通讯作者	Tan, Lili; Zhao, Dewei
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang, Liaoning, Peoples R China 3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Orthoped, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Dong, Jiahui,Tan, Lili,Yang, Jiahui,et al. In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect[J]. MATERIALS TECHNOLOGY,2018,33(6):387-397.
APA	Dong, Jiahui.,Tan, Lili.,Yang, Jiahui.,Wang, Yongxuan.,Chen, Junxiu.,...&Yang, Ke.(2018).In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect.MATERIALS TECHNOLOGY,33(6),387-397.
MLA	Dong, Jiahui,et al."In vitro and in vivo studies on degradation and bone response of Mg-Sr alloy for treatment of bone defect".MATERIALS TECHNOLOGY 33.6(2018):387-397.