Evaluation of promoting effect of a novel Cu-bearing metal stent on endothelialization process from in vitro and in vivo studies

doi:10.1038/s41598-017-17737-9

CORC > 金属研究所 > 中国科学院金属研究所

	Evaluation of promoting effect of a novel Cu-bearing metal stent on endothelialization process from in vitro and in vivo studies
	Jin, Shujing 1,2; Qi, Xun 3,4; Zhang, Bin 5; Sun, Ziqing 1; Zhang, Bingchun 1; Yang, Hui 1; Wang, Tongmin 2; Zheng, Bo 5; Wang, Xingang 5; Shi, Qiuping 5
刊名	SCIENTIFIC REPORTS
	2017-12-12
卷号	7 页码:12
ISSN号	2045-2322
DOI	10.1038/s41598-017-17737-9
通讯作者	Chen, Ming(cm6141@sina.com) ; Ren, Ling(lren@imr.ac.cn) ; Zhong, Hongshan(hszhong@cmu.edu.cn)
英文摘要	Drug eluting stents (DES) have been extensively applied nowadays and reduce the incidence of instent restenosis (ISR) greatly as compared with bare metal stents (BMS). However, the development of DES is hindered by the risk of late stent thrombosis (LST) due to delayed re-endothelialization, while endothelialization is an important process related to ISR and LST after implantation. 316L is a traditional stent material without bioactivity and have a high risk of ISR. Cu is recognized for angiogenesis stimulation in these years. Hence a copper bearing 316L stainless steel (316L-Cu) was prepared and evaluated about its effect on endothelialization in this paper. Compared with traditional 316L, it was proved that 316L-Cu increased the proliferation of co-cultured human umbilical vein endothelial cells (HUVECs) at first day. Moreover, HUVECs stretched better on the surface of 316L-Cu. It also improved the expression of angiogenesis related genes and tube formation ability in vitro. 316L-CuBMS, DES and 316L-BMS were implanted in swine to evaluate the re-endothelialization ability in vivo. And 316L-Cu-BMS showed the best effect on endothelialization with good biosafety. Consequently, 316L-Cu is a kind of promising BMS material for coronary field.
资助项目	National Natural Science Foundation[81301329] ; National Natural Science Foundation[81571778] ; National Natural Science Foundation[81201168] ; Liaoning Province Natural Science Foundation[2015021004] ; Shenyang National Laboratory for materials science[2015021004] ; Youth Innovation Promotion Association, CAS[2014168] ; Natural Science Foundation of Guangdong province[2015A030312004] ; Natural Science Foundation of Liaoning Province[201602850]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000425901300001
资助机构	National Natural Science Foundation ; Liaoning Province Natural Science Foundation ; Shenyang National Laboratory for materials science ; Youth Innovation Promotion Association, CAS ; Natural Science Foundation of Guangdong province ; Natural Science Foundation of Liaoning Province
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/125718]
专题	金属研究所_中国科学院金属研究所
通讯作者	Chen, Ming; Ren, Ling; Zhong, Hongshan
作者单位	1.Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 2.Dalian Univ Technol, Sch Mat Sci & Engn, Dalian 116024, Peoples R China 3.China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang 110001, Liaoning, Peoples R China 4.China Med Univ, Affiliated Hosp 1, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Shenyang 110001, Liaoning, Peoples R China 5.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
推荐引用方式 GB/T 7714	Jin, Shujing,Qi, Xun,Zhang, Bin,et al. Evaluation of promoting effect of a novel Cu-bearing metal stent on endothelialization process from in vitro and in vivo studies[J]. SCIENTIFIC REPORTS,2017,7:12.
APA	Jin, Shujing.,Qi, Xun.,Zhang, Bin.,Sun, Ziqing.,Zhang, Bingchun.,...&Zhong, Hongshan.(2017).Evaluation of promoting effect of a novel Cu-bearing metal stent on endothelialization process from in vitro and in vivo studies.SCIENTIFIC REPORTS,7,12.
MLA	Jin, Shujing,et al."Evaluation of promoting effect of a novel Cu-bearing metal stent on endothelialization process from in vitro and in vivo studies".SCIENTIFIC REPORTS 7(2017):12.