Ionic liquid- functionalized graphene quantum dot- bonded silica as multi- mode HPLC stationary phase with enhanced selectivity for acid compounds

doi:10.1039/c7nj05200f

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Ionic liquid- functionalized graphene quantum dot- bonded silica as multi- mode HPLC stationary phase with enhanced selectivity for acid compounds
	Wu, Qi 1,3,4; Sun, Yaming 1,3,4; Gao, Jie 1,3,4; Chen, Lixiao 1,3,4; Dong, Shuqing 1,3; Luo, Guoying 1,3; Li, Hui 1,3; Wang, Litao 2; Zhao, Liang 1,3
刊名	NEW JOURNAL OF CHEMISTRY
	2018-06-07
卷号	42 期号:11 页码:8672-8680
ISSN号	1144-0546
DOI	10.1039/c7nj05200f
通讯作者	Zhao, Liang(zhaol@licp.cas.cn)
英文摘要	Graphene quantum dots (GQDs), which can form hydrophobic, - stacking, hydrogen bond and hydrophilic interactions with analytes, are a type of multifunctional separation materials. GQD-based stationary phases have great prospects in HPLC. In this study, 1-aminoethyl-3-methylimidazolium bromide ionic liquids (ILs) were chosen as functional molecules to improve the chromatographic performance of GQD-bonded silica stationary phase. This new phase could be applied in multiple separation modes including normal phase, reverse phase, ionic exchange and hydrophilic chromatography modes. Anilines, phenols and polycyclic aromatic hydrocarbons were efficiently separated on the IL/GQD/SiO2 column within 10 minutes in the normal phase and reverse phase modes. Five inorganic anions were baseline separated in the ionic exchange mode. Hydrophilic compounds including alkaloids, glycosides, amino acids and aromatic acids achieved satisfactory resolutions on this stationary phase in the hydrophilic chromatography mode. The separation performance of the IL/GQD/SiO2 column was compared to those of GQD/SiO2 column and IL/SiO2 column; it was found that the IL/GQD/SiO2 column showed better separation performance than the other two columns, which indicated ILs and GQDs had certain synergistic and complementary effects. Introduction of ILs enhanced the separation performance of the GQD-based phase, especially for acid compounds. By investigating the effects of buffer pH, buffer concentration and water content in the mobile phase, it was found that the electrostatic adsorption retention mechanism played a major role in the hydrophilic chromatography mode. This stationary phase, which allows the selection of appropriate separation modes on the basis of analytes, possesses practical prospects after further improvement.
资助项目	National Natural Science Foundation[21405162] ; National Natural Science Foundation[21405161] ; National Natural Science Foundation[21675163] ; National Natural Science Foundation[21702210]
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
资助机构	National Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.licp.cn/handle/362003/27227]
专题	兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
通讯作者	Zhao, Liang
作者单位	1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Gansu, Peoples R China 2.Jining Med Univ, Dept Pharm, Rizhao, Shandong, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wu, Qi,Sun, Yaming,Gao, Jie,et al. Ionic liquid- functionalized graphene quantum dot- bonded silica as multi- mode HPLC stationary phase with enhanced selectivity for acid compounds[J]. NEW JOURNAL OF CHEMISTRY,2018,42(11):8672-8680.
APA	Wu, Qi.,Sun, Yaming.,Gao, Jie.,Chen, Lixiao.,Dong, Shuqing.,...&Zhao, Liang.(2018).Ionic liquid- functionalized graphene quantum dot- bonded silica as multi- mode HPLC stationary phase with enhanced selectivity for acid compounds.NEW JOURNAL OF CHEMISTRY,42(11),8672-8680.
MLA	Wu, Qi,et al."Ionic liquid- functionalized graphene quantum dot- bonded silica as multi- mode HPLC stationary phase with enhanced selectivity for acid compounds".NEW JOURNAL OF CHEMISTRY 42.11(2018):8672-8680.