Ultralong AgNWs-induced toxicity in A549 cells and the important roles of It ROS and autophagy

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境纳米材料实验室

	Ultralong AgNWs-induced toxicity in A549 cells and the important roles of It ROS and autophagy
	Wang, Fengbang ; Wang, Yuanyuan ; Qu, Guangbo ; Yao, Xinglei ; Ma, Chunyan ; Song, Maoyong ; Wang, Hailin ; Jiang, Guibin
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2019-12-30
卷号	186 页码:-
关键词	Ultralong AgNWs Mitochondrial injury ROS Apoptosis Autophagy
ISSN号	0147-6513
英文摘要	Safety concerns have been raised with regard to silver nanowires (AgNWs) because of their extensive applications. Recently, ultralong AgNWs have shown physical properties superior to those of short AgNWs. However, little is known about their toxicity and potential risks. In this study, we demonstrated a series of ultralong AgNWs-induced biological effects in human lung cancer epithelial cells (A549). Ultralong AgNWs treatments induced ROS generation, mitochondria-mediated apoptosis, and self-protective autophagy at nonlethal concentrations. In contrast to some previous reports, apoptosis was found not to correlate with the reduction of intracellular ROS. Measuring the processing of ROS generation, apoptosis and autophagy, we demonstrated that ROS not only enhance mitochondrial damage, but also raise protective autophagic flux in ultralong AgNW-treated cells. Moreover, ultralong AgNWs were found to be internalized into the cytoplasm of the epithelial cells. This study not only investigates ultralong AgNWs-induced cytotoxicity but also pinpoints ROS as a key signal in mechanisms of their toxicity.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/43216]
专题	生态环境研究中心_环境纳米材料实验室
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Fengbang,Wang, Yuanyuan,Qu, Guangbo,et al. Ultralong AgNWs-induced toxicity in A549 cells and the important roles of It ROS and autophagy[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,186:-.
APA	Wang, Fengbang.,Wang, Yuanyuan.,Qu, Guangbo.,Yao, Xinglei.,Ma, Chunyan.,...&Jiang, Guibin.(2019).Ultralong AgNWs-induced toxicity in A549 cells and the important roles of It ROS and autophagy.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,186,-.
MLA	Wang, Fengbang,et al."Ultralong AgNWs-induced toxicity in A549 cells and the important roles of It ROS and autophagy".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 186(2019):-.