Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems
	Jin, Xiaoting ; Ma, Qianchi ; Sun, Zhendong ; Yang, Xuezhi ; Zhou, Qunfang ; Qu, Guangbo ; Liu, Qian ; Liao, Chunyang ; Li, Zhuoyu ; Jiang, Guibin
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2019-03-05
卷号	53 期号:5 页码:2840-2851
ISSN号	0013-936X
英文摘要	Particulate air pollution caused by human activities has drawn global attention due to its potential health risks. Considering the inevitable contact of inhaled airborne fine particulate matter (PM) with plasma, the hematological effects of PM are worthy of study. In this study, the potential effect of PM on hematological homeostasis through triggering the crosstalk of the kallikrein-kinin system (KKS), complement, and coagulation systems in plasma was investigated. The ex vivo, in vitro, and in vivo KKS activation assays confirmed that PM samples could efficiently cause the cascade activation of key zymogens in the KKS, wherein the particles coupled with lipopolysaccharide attachment provided substantial contribution. The binding of Hageman factor XII (FXII) with PM samples and its subsequent autoactivation initiated this process. The crucial elements in the complement cascade, including complement (C3) and complement 5 (C5), and coagulation system (prothrombin) were also found to be actively induced by PM exposure, which was regulated by the interplay of KKS activation. The data provided solid evidence on hematological effects of airborne PM through inducing the activation of the KKS, complement, and coagulation systems, which would be valuable in the risk assessment on air-pollution-related cardiovascular diseases.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42897]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 3.Shanxi Univ, Inst Biomed Sci, Taiyuan 030006, Shanxi, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Jin, Xiaoting,Ma, Qianchi,Sun, Zhendong,et al. Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(5):2840-2851.
APA	Jin, Xiaoting.,Ma, Qianchi.,Sun, Zhendong.,Yang, Xuezhi.,Zhou, Qunfang.,...&Jiang, Guibin.(2019).Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(5),2840-2851.
MLA	Jin, Xiaoting,et al."Airborne Fine Particles Induce Hematological Effects through Regulating the Crosstalk of the Kallikrein-Kinin, Complement, and Coagulation Systems".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.5(2019):2840-2851.