The Lasting Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Resting State EEG in Healthy Subjects

doi:10.1109/TNSRE.2020.2977883

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	The Lasting Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Resting State EEG in Healthy Subjects
	Qiu, Shuang 3; Yi, Weibo 2; Wang, Shengpei 1,3; Zhang, Chuncheng 3; He, Huiguang 1,3,4
刊名	IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
	2020-04-01
卷号	28 期号:4 页码:832-841
关键词	Electroencephalography Transcranial magnetic stimulation Band-pass filters Finite impulse response filters Indexes Automation Modulation Repetitive transcranial magnetic stimulation low-frequency resting state EEG power functional connectivity
ISSN号	1534-4320
DOI	10.1109/TNSRE.2020.2977883
通讯作者	Qiu, Shuang(shuang.qiu@ia.ac.cn) ; He, Huiguang(huiguang.he@ia.ac.cn)
英文摘要	Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that can influence cortical excitability. Low-frequency rTMS (stimulation frequency <= 1Hz) can induce inhibitory effects on cortical excitability. In order to investigate dynamic changes in neuronal activity after low-frequency rTMS, 20 healthy subjects received 1-Hz rTMS over the right motor area, and electroencephalography (EEG) in resting condition with eyes open was recorded before rTMS and at 0 min, 20 min, 40 min, and 60 min after rTMS. Power values, functional connectivity based on a weighted phase lag index (wPLI), and network characteristics were assessed and compared to study the aftereffects of rTMS. Our results show that low-frequency rTMS produced a delayed long-lasting increase in alpha-band power values in frontoparietal brain areas and an immediate long-lasting increase in theta-band power values in the ipsilateral frontal and contralateral centroparietal areas. In the alpha band, functional connectivity decreased immediately after rTMS but significantly increased at 20 min after rTMS. Moreover, an analysis of undirected graphs revealed that the number of connections significantly changed in the anterior and posterior regions in the alpha band. In addition, there were significant decreases in clustering coefficients of the channels near the site of stimulation in the alpha and theta bands after rTMS. In conclusion, low-frequency rTMS produces widespread and long-lasting alterations in neural oscillation and functional connectivity. This work implies that low-frequency rTMS can induce inhibitory effects on motor cortical excitability ipsilateral to the stimulation site.
资助项目	National Natural Science Foundation of China[81701785] ; National Natural Science Foundation of China[61976209] ; National Natural Science Foundation of China[61906188] ; Strategic Priority Research Program of Chinese Academy of Sciences (CAS)[XDB32040000] ; China Postdoctoral Science Foundation[2019M650893]
WOS关键词	MOTOR CORTEX ; CORTICAL EXCITABILITY ; RTMS ; MODULATION ; STROKE ; CONNECTIVITY ; TMS ; DEPRESSION ; PLASTICITY ; INDUCTION
WOS研究方向	Engineering ; Rehabilitation
语种	英语
出版者	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
WOS记录号	WOS:000527793800007
资助机构	National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences (CAS) ; China Postdoctoral Science Foundation
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/39347]
专题	类脑智能研究中心_神经计算及脑机交互
通讯作者	Qiu, Shuang; He, Huiguang
作者单位	1.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing 100049, Peoples R China 2.Beijing Machine & Equipment Inst, Beijing 100854, Peoples R China 3.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Qiu, Shuang,Yi, Weibo,Wang, Shengpei,et al. The Lasting Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Resting State EEG in Healthy Subjects[J]. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING,2020,28(4):832-841.
APA	Qiu, Shuang,Yi, Weibo,Wang, Shengpei,Zhang, Chuncheng,&He, Huiguang.(2020).The Lasting Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Resting State EEG in Healthy Subjects.IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING,28(4),832-841.
MLA	Qiu, Shuang,et al."The Lasting Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Resting State EEG in Healthy Subjects".IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING 28.4(2020):832-841.