A neuroimaging biomarker for striatal dysfunction in schizophrenia | |
Li, Ang1,27,28,29; Zalesky, Andrew24,25,26; Yue, Weihua21,22,23; Howes, Oliver19,20; Yan, Hao21,22,23; Liu, Yong1,27,28,29; Fan, Lingzhong1,27,28,29; Whitaker, Kirstie J.17,18; Xu, Kaibin1,28,29; Rao, Guangxiang1,27,28,29 | |
刊名 | NATURE MEDICINE |
2020-03-23 | |
卷号 | 26期号:26页码:27 |
关键词 | TREATMENT-RESISTANT SCHIZOPHRENIA,RESTING-STATE FMRI,FUNCTIONAL CONNECTIVITY,DOPAMINE HYPOTHESIS,GENE-EXPRESSION,NETWORK |
ISSN号 | 1078-8956 |
DOI | 10.1038/s41591-020-0793-8 |
通讯作者 | Jiang, Tianzi(Jiangtz@nlpr.ia.ac.cn) ; Liu, Bing(bliu@nlpria.ac.cn) |
英文摘要 | Mounting evidence suggests that function and connectivity of the striatum is disrupted in schizophrenia(1-5). We have developed a new hypothesis-driven neuroimaging biomarker for schizophrenia identification, prognosis and subtyping based on functional striatal abnormalities (FSA). FSA scores provide a personalized index of striatal dysfunction, ranging from normal to highly pathological. Using inter-site cross-validation on functional magnetic resonance images acquired from seven independent scanners (n = 1,100), FSA distinguished individuals with schizophrenia from healthy controls with an accuracy exceeding 80% (sensitivity, 79.3%; specificity, 81.5%). In two longitudinal cohorts, inter-individual variation in baseline FSA scores was significantly associated with antipsychotic treatment response. FSA revealed a spectrum of severity in striatal dysfunction across neuropsychiatric disorders, where dysfunction was most severe in schizophrenia, milder in bipolar disorder, and indistinguishable from healthy individuals in depression, obsessive-compulsive disorder and attention-deficit hyperactivity disorder. Loci of striatal hyperactivity recapitulated the spatial distribution of dopaminergic function and the expression profiles of polygenic risk for schizophrenia. In conclusion, we have developed a new biomarker to index striatal dysfunction and established its utility in predicting antipsychotic treatment response, clinical stratification and elucidating striatal dysfunction in neuropsychiatric disorders. A new cross-validated neuroimaging biomarker that reflects striatal dysfunctioning can be used to distinguish patients with schizophrenia from healthy controls, and is associated with treatment response to antipsychotics. |
资助项目 | National Key Basic Research and Development Program (973)[2011CB707800] ; National Key Research and Development Plan[2016YFC0904300] ; Strategic Priority Research Program of Chinese Academy of Science[XDB32020200] ; Natural Science Foundation of China[81771451] |
WOS关键词 | TREATMENT-RESISTANT SCHIZOPHRENIA ; RESTING-STATE FMRI ; FUNCTIONAL CONNECTIVITY ; DOPAMINE HYPOTHESIS ; GENE-EXPRESSION ; NETWORK ; PSYCHOSIS ; RISK ; DYSCONNECTIVITY ; DISORDER |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology ; Research & Experimental Medicine |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000521529700004 |
资助机构 | National Key Basic Research and Development Program (973) ; National Key Research and Development Plan ; Strategic Priority Research Program of Chinese Academy of Science ; Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/38706] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Jiang, Tianzi; Liu, Bing |
作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia 3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuro Informat, Chengdu, Peoples R China 4.Chinese Acad Sci, Innovat Acad Artificial Intelligence, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 6.Peking Univ, McGovern Inst Brain Res, PKU IDG, Ctr Life Sci, Beijing, Peoples R China 7.Kunming Med Univ, Affiliated Hosp 1, Dept Psychiat, Kunming, Yunnan, Peoples R China 8.Shanxi Univ, Sch Comp & Informat Technol, Taiyuan, Peoples R China 9.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Peoples R China 10.Xinxiang Med Univ, Dept Psychol, Xinxiang, Henan, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Ang,Zalesky, Andrew,Yue, Weihua,et al. A neuroimaging biomarker for striatal dysfunction in schizophrenia[J]. NATURE MEDICINE,2020,26(26):27. |
APA | Li, Ang.,Zalesky, Andrew.,Yue, Weihua.,Howes, Oliver.,Yan, Hao.,...&Liu, Bing.(2020).A neuroimaging biomarker for striatal dysfunction in schizophrenia.NATURE MEDICINE,26(26),27. |
MLA | Li, Ang,et al."A neuroimaging biomarker for striatal dysfunction in schizophrenia".NATURE MEDICINE 26.26(2020):27. |
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