Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors

doi:10.1002/adhm.202000394

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors
	Zhang, Ruili 1; Wang, Linlin 1; Wang, Xiaofei 1; Jia, Qian 1; Chen, Zhuang 1; Yang, Zuo 1; Ji, Renchuan 1; Tian, Jie 1,2,3; Wang, Zhongliang 1
刊名	ADVANCED HEALTHCARE MATERIALS
	2020-06-16
页码	10
关键词	cancer theranostics gold nanoparticles in vivo self-assembly photothermal therapy tumor microenvironments
ISSN号	2192-2640
DOI	10.1002/adhm.202000394
通讯作者	Wang, Zhongliang(wangzl@xidian.edu.cn)
英文摘要	The complexity of biological systems poses a great challenge in the development of nanotheranostic agents with enhanced therapeutic efficacies. To systematically overcome a series of barriers during in vivo administration and achieve optimal antitumor activity, nanotheranostic agents that can self-adaptively change their properties in response to certain tumor-associated signals are highly preferable. Herein, gold nanoparticles with a mixed-charge zwitterionic surface (Au-MUA-TMA) is fabricated, which can undergo pH-triggered self-assembly for promoting tumor targeting and improving photoacoustic imaging (PAI)-guided photothermal tumor ablation. In blood and normal tissues, relatively small-sized Au-MUA-TMA can circulate stably, and upon arriving at the tumor sites, they quickly assemble into larger aggregates in an acidic tumor environment to ensure higher tumor accumulation and retention. Furthermore, the absorption band of Au-MUA-TMA can be remarkably shifted to the near-infrared (NIR) region, which effectively activates the photoacoustic (PA) signals of tumors and enhances photothermal therapy (PTT) with minimal side effects. This in vivo self-assembly strategy enables the nanotheranostic agents to better fulfill multiple requirements for in vivo application, thereby attaining advanced performances in cancer diagnosis and treatment.
资助项目	National Key Research and Development Program of China[2017YFC1309100] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671753] ; National Natural Science Foundation of China[91959124] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[21804104] ; National Natural Science Foundation of China[81501524] ; National 1000 Young Talents Program of China ; Natural Science Foundation of Shaanxi Province[2019JQ-139] ; Natural Science Foundation of Shaanxi Province[2018JM2041] ; Fundamental Research Funds for the Central Universities[JB191211] ; Fundamental Research Funds for the Central Universities[JB191207] ; Fundamental Research Funds for the Central Universities[JB191208]
WOS关键词	DRUG-DELIVERY ; RAMAN-SCATTERING ; CELLULAR UPTAKE ; PH ; NANOTHERANOSTICS ; RETENTION ; NANOCAGES ; MICELLES ; RELEASE ; POLYMER
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000540291400001
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; National 1000 Young Talents Program of China ; Natural Science Foundation of Shaanxi Province ; Fundamental Research Funds for the Central Universities
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/39753]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Wang, Zhongliang
作者单位	1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuroimaging, Minist Educ, Xian 710126, Shaanxi, Peoples R China 2.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Ruili,Wang, Linlin,Wang, Xiaofei,et al. Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors[J]. ADVANCED HEALTHCARE MATERIALS,2020:10.
APA	Zhang, Ruili.,Wang, Linlin.,Wang, Xiaofei.,Jia, Qian.,Chen, Zhuang.,...&Wang, Zhongliang.(2020).Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors.ADVANCED HEALTHCARE MATERIALS,10.
MLA	Zhang, Ruili,et al."Acid-Induced In Vivo Assembly of Gold Nanoparticles for Enhanced Photoacoustic Imaging-Guided Photothermal Therapy of Tumors".ADVANCED HEALTHCARE MATERIALS (2020):10.