Noninvasive CT radiomic model for preoperative prediction of lymph node metastasis in early cervical carcinoma | |
Chen, Jiaming1,2; He, Bingxi3,4,5; Dong, Di3,5; Liu, Ping1,2; Duan, Hui1,2; Li, Weili1,2; Li, Pengfei1,2; Wang, Lu1,2; Fan, Huijian1,2; Wang, Siwen3,5 | |
刊名 | BRITISH JOURNAL OF RADIOLOGY |
2020 | |
卷号 | 93期号:1108页码:8 |
ISSN号 | 0007-1285 |
DOI | 10.1259/bjr.20190558 |
通讯作者 | Tian, Jie(jie.tian@ia.ac.cn) ; Huang, Zhipei(zhphuang@ucas.ac.cn) ; Chen, Chunlin(ccl1@smu.edu.cn) |
英文摘要 | Objective: To build and validate a CT radiomic model for pre-operatively predicting lymph node metastasis in early cervical carcinoma. Methods and materials: A data set of 150 patients with Stage IB1 to IIA2 cervical carcinoma was retrospectively collected from the Nanfang hospital and separated into a training cohort (n = 104) and test cohort (n = 46). A total of 348 radiomic features were extracted from the delay phase of CT images. Mann-Whitney U test, recursive feature elimination, and backward elimination were used to select key radiomic features. Ridge logistics regression was used to build a radiomic model for prediction of lymph node metastasis (LNM) status by combining radiomic and clinical features. The area under the receiver operating characteristic curve (AUC) and kappa test were applied to verify the model. Results: Two radiomic features from delay phase CT images and one clinical feature were associated with LNM status: log-sigma-2-Omm-3D_glcm_Idn (p 0.01937), wavelet-HL_firstorder_Median (p = 0.03592), and Stage IB (p = 0.03608). Radiomic model was built consisting of the three features, and the AUCs were 0.80 (95% confidence interval: 0.70 - 0.90) and 0.75 (95% confidence intervall: 0.53 - 0.93) in training and test cohorts, respectively. The kappa coefficient was 0.84, showing excellent consistency. Conclusion: A non-invasive radiomic model, combining two radiomic features and a International Federation of Gynecology and Obstetrics stage, was built for prediction of LNM status in early cervical carcinoma. This model could serve as a pre-operative tool. Advances in knowledge: A noninvasive CT radiomic model, combining two radiomic features and the International Federation of Gynecology and Obstetrics stage, was built for prediction of LNM status in early cervical carcinoma. |
资助项目 | National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1309100] ; National Key R&D Program of China[2017YFC1308701] ; National Key R&D Program of China[2016YFC0103803] ; National Key R&D Program of China[2017YFA0700401] ; National Natural Science Foundation of China[81571422] ; National Natural Science Foundation of China[81370736] ; National Natural Science Foundation of China[81771924] ; National Natural Science Foundation of China[81501616] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[61671449] ; National Natural Science Foundation of China[61622117] ; National Science and Technology Support Program of China[2014BAI05B03] ; National Natural Science Fund of Guangdong[2015A030311024] ; Science and Technology Plan of Guangzhou[158100075] ; Beijing Municipal Science and Technology Commission[Z171100000117023] ; Beijing Municipal Science and Technology Commission[Z161100002616022] ; Instrument Developing Project of the Chinese Academy of Sciences[YZ201502] ; Youth Innovation Promotion Association CAS[2017175] |
WOS关键词 | PELVIC LYMPHADENECTOMY ; ENDOMETRIAL CANCER ; COMPLICATIONS ; ADENOCARCINOMA ; ACCURACY ; NOMOGRAM |
WOS研究方向 | Radiology, Nuclear Medicine & Medical Imaging |
语种 | 英语 |
出版者 | BRITISH INST RADIOLOGY |
WOS记录号 | WOS:000521530600007 |
资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; National Science and Technology Support Program of China ; National Natural Science Fund of Guangdong ; Science and Technology Plan of Guangzhou ; Beijing Municipal Science and Technology Commission ; Instrument Developing Project of the Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/38700] |
专题 | 自动化研究所_中国科学院分子影像重点实验室 |
通讯作者 | Tian, Jie; Huang, Zhipei; Chen, Chunlin |
作者单位 | 1.Southern Med Univ, Nanfang Hosp, Dept Obstet & Gynecol, Guangzhou, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Digital Med Lab, Dept Obstet & Gynecol, Guangzhou, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Sch Elect Elect & Commun Engn, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Jiaming,He, Bingxi,Dong, Di,et al. Noninvasive CT radiomic model for preoperative prediction of lymph node metastasis in early cervical carcinoma[J]. BRITISH JOURNAL OF RADIOLOGY,2020,93(1108):8. |
APA | Chen, Jiaming.,He, Bingxi.,Dong, Di.,Liu, Ping.,Duan, Hui.,...&Chen, Chunlin.(2020).Noninvasive CT radiomic model for preoperative prediction of lymph node metastasis in early cervical carcinoma.BRITISH JOURNAL OF RADIOLOGY,93(1108),8. |
MLA | Chen, Jiaming,et al."Noninvasive CT radiomic model for preoperative prediction of lymph node metastasis in early cervical carcinoma".BRITISH JOURNAL OF RADIOLOGY 93.1108(2020):8. |
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