New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388

doi:10.1002/cbdv.202000320

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388
	Chi, Lu-Ping 1,2,3; Li, Xiao-Ming 2,3; Li, Xin 2,3; Wang, Bin-Gui 2,3,4
刊名	CHEMISTRY & BIODIVERSITY
	2020-07-20
页码	7
关键词	deep sea-derived fungus Epicoccum nigrum thiodiketopiperazines antibacterial activity
ISSN号	1612-1872
DOI	10.1002/cbdv.202000320
英文摘要	Two new antibacterial thiodiketopiperazine derivatives (TDKPs), 7-dehydroxyepicoccin H and 7-hydroxyeutypellazine F, along with seven known TDKP analogs, were isolated and identified fromEpicoccum nigrumSD-388, a deep-sea-sediment-derived fungus. The structures of these compounds were elucidated on the basis of detailed spectroscopic analysis. The absolute configuration of 7-dehydroxyepicoccin H was established by X-ray crystallographic analysis, while 7-hydroxyeutypellazine F was determined by ECD experiment and TDDFT-ECD calculation. The antibacterial activities against human and aquatic pathogens were evaluated. 7-Dehydroxyepicoccin H and 7-hydroxyeutypellazine F displayed inhibitory activities against aquatic pathogensVibrio vulnificus,V. alginolyticus, andEdwardsiella tarda, with MIC values ranging from 4.0 to 8.0 mu g/mL.
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050401] ; Shandong Provincial Natural Science Foundation[ZR2019ZD18] ; Basic Applied Research program of Qingdao[19-6-2-40-cg] ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences[KEXUE2018G28] ; Taishan Scholar Project from Shandong Province[ts201511060]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000550490700001
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/167951]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Xin; Wang, Bin-Gui
作者单位	1.Univ Chinese Acad Sci, Yuquan Rd 19 A, Beijing 100049, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Li, Xiao-Ming,Li, Xin,et al. New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388[J]. CHEMISTRY & BIODIVERSITY,2020:7.
APA	Chi, Lu-Ping,Li, Xiao-Ming,Li, Xin,&Wang, Bin-Gui.(2020).New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388.CHEMISTRY & BIODIVERSITY,7.
MLA	Chi, Lu-Ping,et al."New Antibacterial Thiodiketopiperazines from the Deep Sea Sediment-Derived FungusEpicoccum nigrumSD-388".CHEMISTRY & BIODIVERSITY (2020):7.