Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants

doi:10.1016/j.carbpol.2021.118050

CORC > 海洋研究所 > 中国科学院海洋研究所

	Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants
	Li, Xiaomin 1,2,3,4; Xing, Ronge 1,2,3,4; Xu, Chaojie 1,2,3,4; Liu, Song 1,3,4; Qin, Yukun 1,3,4; Li, Kecheng 1,3,4; Yu, Huahua 1,3,4; Li, Pengcheng 1,3,4
刊名	CARBOHYDRATE POLYMERS
	2021-07-15
卷号	264 页码:16
关键词	Chitosan Quaternized chitosan Immunostimulatory activities Immune mechanism Vaccine adjuvant
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2021.118050
通讯作者	Xing, Ronge(xingronge@qdio.ac.cn)
英文摘要	Vaccines have always been the most effective preventive treatment. Advancements in the field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines to enhance immunogenicity and induce a stronger immune response. Chitosan fascinated considerable attention as vaccine adjuvant due to its unique physicochemical and biological properties. Many studies have shown that chitosan and its derivatives can effectively activate antigen-presenting cells and induce cytokine stimulation to produce an effective immune response and promote the balance of Th1/Th2 response. Among many derivatives, the quaternized chitosan performs better. This review presents the main factors affecting the adjuvant performance of chitosan and quaternized chitosan firstly. Then, we introduced not only the immune response they may cause, but also their metabolic research in detail. Furthermore, their future prospects are forecasted. Overall, chitosan and quaternized chitosan are both promising adjuvant materials, and quaternized chitosan shows greater potential.
资助项目	National Key R&D Program of China[2018YFC0311300] ; Key Research and Development Program of Shandong Province[2019GHY112015] ; Key Research and Development Program of Shandong Province[2019YYSP028]
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000647409300001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/170943]
专题	中国科学院海洋研究所
通讯作者	Xing, Ronge
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Li, Xiaomin,Xing, Ronge,Xu, Chaojie,et al. Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants[J]. CARBOHYDRATE POLYMERS,2021,264:16.
APA	Li, Xiaomin.,Xing, Ronge.,Xu, Chaojie.,Liu, Song.,Qin, Yukun.,...&Li, Pengcheng.(2021).Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants.CARBOHYDRATE POLYMERS,264,16.
MLA	Li, Xiaomin,et al."Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants".CARBOHYDRATE POLYMERS 264(2021):16.