Mercury (Hg) is a global pollutant that affects environmental and human health. Considering the high toxicity of Hg, it is required to assess the exposure of Hg in human body for appropriate risk management. In this review paper, we summarized data obtained through regional and small-scaled human biomonitoring (HBM) program for Hg in hair samples in China, which can deliver scientific data to make decisions on environmental health policy. Besides, the major conclusions got from this study and perspectives for future works through these HBM program in China were presented. To better understand the current situation of hair Hg levels in China, a well-coordinated and designed national HBM program is urgently needed considering the requirements of the Minamata Convention on Mercury for effectiveness evaluation.