Engineered Bacillus subtilis biofilms as living glues

doi:10.1016/j.mattod.2018.12.039

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Engineered Bacillus subtilis biofilms as living glues
	Zhang, C ; Huang, JF ; Zhang, JC ; Liu, SY ; Cui, MK ; An, BL ; Wang, XY ; Pu, JH ; Zhao, TX ; Fan, CH
刊名	MATERIALS TODAY
	2019
卷号	28 页码:40-48
关键词	MUSSEL FOOT PROTEINS UNDERWATER ADHESIVE SURFACE COACERVATION CHEMISTRY STICKING FIBERS PLAQUE
ISSN号	1369-7021
DOI	10.1016/j.mattod.2018.12.039
文献子类	期刊论文
英文摘要	The powerful biological adhesion systems of barnacles, mussels, and other marine animals have led to bio-inspired adhesives with impressive performance characteristics. However, lacking the capacities that only cells possess (e.g., self-regeneration, environmental responsiveness, etc.), these artificial materials cannot exploit the full potential of the natural adhesive systems that inspired them. Here, we developed "functional cellular glues" made of Bacillus subtilis biofilms-tightly associated bacteria encased in an extracellular matrix-that contain both an engineered amyloid protein functionalized with a mussel foot protein and an engineered hydrophobin-like protein. We demonstrate proof-of-concept for both tunable adhesion performance via inducible enzymatic modification and for improved adhesion through metal ion-assisted curing. By conceptualizing biofilms themselves-rather than individual material components-as adhesives, we have developed an evolvable engineering platform that opens the door to make smart living glues with dynamic, self-healing, and other previously unattainable material properties.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/32046]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China; 2.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China; 4.MIT, Res Lab Elect, Synthet Biol Grp, 77 Massachusetts Ave, Cambridge, MA 02139 USA 5.ShanghaiTech Univ, Sch Phys Sci & Technol, Mat & Phys Biol Div, Shanghai 201210, Peoples R China; 6.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China; 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 8.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China;
推荐引用方式 GB/T 7714	Zhang, C,Huang, JF,Zhang, JC,et al. Engineered Bacillus subtilis biofilms as living glues[J]. MATERIALS TODAY,2019,28:40-48.
APA	Zhang, C.,Huang, JF.,Zhang, JC.,Liu, SY.,Cui, MK.,...&Zhong, C.(2019).Engineered Bacillus subtilis biofilms as living glues.MATERIALS TODAY,28,40-48.
MLA	Zhang, C,et al."Engineered Bacillus subtilis biofilms as living glues".MATERIALS TODAY 28(2019):40-48.