Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma

doi:10.1016/j.bioorg.2019.103256

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma
	Wei, Wen-Jun 1; Qi, Weiyan 2; Gao, Xin-Mei 2; Feng, Ke-Na 3,4; Ma, Kai-Liang 1; Li, Hang-Ying 1; Li, Ya 1; Gao, Kun 1
刊名	BIOORGANIC CHEMISTRY
	2019-12-01
卷号	93 页码:10
关键词	Euphorbia hylonoma ent-Isopimarane ent-Rosane Anti-inflammatory
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2019.103256
通讯作者	Li, Ya(liea@lzu.edu.cn) ; Gao, Kun(npchem@lzu.edu.cn)
英文摘要	A phytochemical investigation to obtain chemical components with potential anti-inflammatory activity from E. hylonoma led to the isolation of nine new ent-isopimarane diterpenoids (1 and 3-10), a new ent-rosane diterpenoid (11), along with eight known ones (2 and 12-18) using various chromatographic techniques. Compounds 3, 4, 5, and 10 were rare examples of the epoxy-ent-isopimarane. The structures of these new compounds were confirmed by extensive spectroscopic data, crystal X-ray diffraction analysis, and electronic circular dichroism. And the isolates were evaluated for their inhibitory effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells. The results showed that compounds 2 and 12 exhibited noteworthy inhibitory effects against NO production with IC50 values of 7.12 and 12.73 mu M, respectively, which were better than positive control (IC50 = 41.41 mu M). The possible mechanism that compounds 2 and 12 could inhibit NO production was investigated by the Western blotting experiments.
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
WOS记录号	WOS:000499717000017
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70693]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Li, Ya; Gao, Kun
作者单位	1.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 2.China Pharmaceut Univ, Sch Life Sci & Technol, Dept Marine Pharm, Nanjing 211198, Jiangsu, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Wei, Wen-Jun,Qi, Weiyan,Gao, Xin-Mei,et al. Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma[J]. BIOORGANIC CHEMISTRY,2019,93:10.
APA	Wei, Wen-Jun.,Qi, Weiyan.,Gao, Xin-Mei.,Feng, Ke-Na.,Ma, Kai-Liang.,...&Gao, Kun.(2019).Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma.BIOORGANIC CHEMISTRY,93,10.
MLA	Wei, Wen-Jun,et al."Anti-inflammatory evaluation and structure-activity relationships of diterpenoids isolated from Euphorbia hylonoma".BIOORGANIC CHEMISTRY 93(2019):10.