Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis
	Ling Yi 1,2; Teng Lin-Lin 1,2,3; Hua Juan 1,2; Li De-Sen 1,2,3; Luo Shi-Hong 1,2; Liu Yan-Chun 1,2; Liu Yan 1,2; Li Sheng-Hong 1,2
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2019-12-01
卷号	17 期号:12 页码:892-899
关键词	Sesterterpenoid Leucosceptroid B Leucosceptrum canum Caenorhabditis elegans Fat accumulation Fatty acid biosynthesis Antilipemic agent
ISSN号	2095-6975
通讯作者	Liu Yan(liuyan@mail.kib.ac.cn) ; Li Sheng-Hong(shli@mail.kib.ac.cn)
英文摘要	Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis elegans. Furthermore, leucosceptroid B was found to reduce fat storage, and downregulate the expression of two stearoyl-CoA desaturase (SCD) genes fat-6 and fat-7, and a fatty acid elongase gene elo-2 in wild-type C. elegans. In addition, leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6; fat-7 double mutant. These findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6, fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty acid. These findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents.
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000504330400004
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70666]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Liu Yan; Li Sheng-Hong
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ling Yi,Teng Lin-Lin,Hua Juan,et al. Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(12):892-899.
APA	Ling Yi.,Teng Lin-Lin.,Hua Juan.,Li De-Sen.,Luo Shi-Hong.,...&Li Sheng-Hong.(2019).Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis.CHINESE JOURNAL OF NATURAL MEDICINES,17(12),892-899.
MLA	Ling Yi,et al."Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis".CHINESE JOURNAL OF NATURAL MEDICINES 17.12(2019):892-899.