Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels

doi:10.1080/14786419.2020.1712387

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels
	Xin, Ying 1,4; Xu, Min 4; Wang, Ya-Feng 2; Zheng, Xiao-Hong 4; Zhu, Hong-Tao 3,4; Wang, Dong 3,4; Yang, Chong-Ren 4; Zhang, Ying-Jun 3,4
刊名	NATURAL PRODUCT RESEARCH
	2020-01-24
页码	8
关键词	Phyllanthus acidus phyllanthacidoid U norbisabolane sesquiterpenoid amide
ISSN号	1478-6419
DOI	10.1080/14786419.2020.1712387
通讯作者	Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn)
英文摘要	A novel highly oxygenated norbisabolane sesquiterpene, namely phyllanthacidoid U (1), along with nine known sesquiterpenes (2-10) was isolated from the roots and stems of Phyllanthus acidus (L.) Skeels (Phyllanthaceae), collected from Xishuangbanna, Yunnan province, China. Their structures were elucidated by means of extensive spectroscopic analysis and by comparison of their data with reported values in literatures. Instead of the C-13 ester O-glycosyl found mostly in the titled plant growing in Thailand, compound 1 possessed a rare N-beta-glucosamine-2-N-acetate moiety linked directly to the carbonyl at C-13 through an amido bond. Moreover, the acyl group at C-10 in 1 was (Z)-2-(2-hydroxyethyl)-pent-2-enedioyl group, instead of benzoic or p-hydroxybenzoic moieties found commonly in the reported norbisabolane sesquiterpenes. The known sesquiterpene 5 displayed stronger anti hepatitis B virus (HBV) activity with IC50 values of 1.69 +/- 0.22 and 2.79 +/- 0.69 mu M towards HBV surface antigen (HBsAg) and HBV excreted antigen (HBeAg) secretion, respectively.
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000509172800001
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70649]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhang, Ying-Jun
作者单位	1.Chongqing Three Gorges Med Coll, Chongqing, Peoples R China 2.Zhengzhou Univ, Coll Pharmaceut Sci, Zhengzhou, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming, Yunnan, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Xin, Ying,Xu, Min,Wang, Ya-Feng,et al. Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels[J]. NATURAL PRODUCT RESEARCH,2020:8.
APA	Xin, Ying.,Xu, Min.,Wang, Ya-Feng.,Zheng, Xiao-Hong.,Zhu, Hong-Tao.,...&Zhang, Ying-Jun.(2020).Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels.NATURAL PRODUCT RESEARCH,8.
MLA	Xin, Ying,et al."Phyllanthacidoid U: a new N-glycosyl norbisabolane sesquiterpene from Phyllanthus acidus (L.) skeels".NATURAL PRODUCT RESEARCH (2020):8.