Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study

doi:10.1093/schbul/sbaa089

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	Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study
	Ferruccio, Naika P.2; Tosato, Sarah 2,3; Lappin, Julia M.1; Heslin, Margaret 9; Donoghue, Kim 8; Giordano, Annalisa 2; Lomas, Ben 7; Reininghaus, Ulrich 6; Onyejiaka, Adanna 2; Chan, Raymond C. K.5
刊名	SCHIZOPHRENIA BULLETIN
	2021
卷号	47 期号:1 页码:118-127
关键词	neurological signs first-episode psychosis clinical outcome remission
ISSN号	0586-7614
DOI	10.1093/schbul/sbaa089
通讯作者	Dazzan, Paola(paola.dazzan@kcl.ac.uk)
英文摘要	Minor neurological signs are subtle deficits in sensory integration, motor coordination, and sequencing of complex motor acts present in excess in the early stages of psychosis. Still, it remains unclear whether at least some of these signs represent trait or state markers for psychosis and whether they are markers of long-term disease outcome of clinical utility. We examined the relationship between neurological function at illness onset assessed with the Neurological Evaluation Scale and subsequent illness course in 233 patients from AESOP-10 (Aetiology and Ethnicity in Schizophrenia and Other Psychoses), a 10-year follow-up study of a population-based cohort of individuals recruited at the time of their first episode of psychosis in the United Kingdom. In 56 of these patients, we also explored changes in neurological function over time. We included a group of 172 individuals without psychosis as controls. After 10 years, 147 (63%) patients had developed a non-remitting course of illness, and 86 (37%) a remitting course. Already at first presentation, patients who developed a non-remitting course had significantly more primary, motor coordination, and total signs than both remitting patients and healthy controls. While Motor Coordination signs did not change over time, rates of Primary, Sensory Integration, and Total signs increased, independently of illness course type. These findings suggest that motor coordination problems could be a useful early, quick, and easily detectable marker of subsequent clinical outcome. With other motor abnormalities, a measure of motor incoordination could contribute to the identification of the most vulnerable individuals, who could benefit from targeted and more assertive treatment approaches.
资助项目	UK Medical Research Council[G0500817] ; Department of Health via the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
WOS关键词	SOFT SIGNS ; 1ST-EPISODE SCHIZOPHRENIA ; FOLLOW-UP ; NEGATIVE SYMPTOMS ; CLINICAL-COURSE ; RATING-SCALE ; ABNORMALITIES ; STABILITY ; RISK ; PSYCHOPATHOLOGY
WOS研究方向	Psychiatry
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000649368900016
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/39395]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Dazzan, Paola
作者单位	1.Univ New South Wales, Fac Med, Sch Psychiat, Sydney, NSW, Australia 2.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England 3.Univ Verona, Dept Neurosci Biomed & Movement Sci, Sect Psychiat, Verona, Italy 4.Univ Dundee, Sch Hlth Sci, Dundee, Scotland 5.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Publ Mental Hlth, Heidelberg, Germany 7.Univ Nottingham, Dept Psychiat, Nottingham, England 8.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Addict, London, England 9.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Hlth Serv & Populat Res, London, England 10.Kings Coll London, London, England
推荐引用方式 GB/T 7714	Ferruccio, Naika P.,Tosato, Sarah,Lappin, Julia M.,et al. Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study[J]. SCHIZOPHRENIA BULLETIN,2021,47(1):118-127.
APA	Ferruccio, Naika P..,Tosato, Sarah.,Lappin, Julia M..,Heslin, Margaret.,Donoghue, Kim.,...&Dazzan, Paola.(2021).Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study.SCHIZOPHRENIA BULLETIN,47(1),118-127.
MLA	Ferruccio, Naika P.,et al."Neurological Signs at the First Psychotic Episode as Correlates of Long-Term Outcome: Results From the AESOP-10 Study".SCHIZOPHRENIA BULLETIN 47.1(2021):118-127.